Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)
Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)
复制标题
三环唑对斑马鱼（Danio rerio）的肝毒性
DOI：
10.1016/j.chemosphere.2019.05.159
复制
发表时间：
2019
期刊：
影响因子：
8.8
通讯作者：
Lu Huiqiang
中科院分区：
文献类型：
--
作者：
Qiu Lingyu;Jia Kun;Huang Lirong;Liao Xinjun;Guo Xinchun;Lu Huiqiang
三环唑作为一种农药广泛应用于农业，但其在脊椎动物中的毒性目前评价得很差。在这项研究中，我们使用斑马鱼来评估三环唑的毒性。我们发现，三环唑诱导肝损伤，或肝毒性，在斑马鱼，在发育和成年。在胚胎中，我们发现三环唑影响肝脏发育，而不是其他内胚层组织，如肠道和胰腺。在胚胎和成年斑马鱼肝脏中，三环唑破坏了氧化和抗氧化系统之间的关系，导致活性氧（ROS）超载。同时，它还可引起肝细胞凋亡，干扰糖/脂代谢和能量需求系统。这些结果表明，三环唑可引起严重后果的脊椎动物肝脏发育和功能。
Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development and adulthood. In embryos, we found that tricyclazole affected the liver development rather than other endodermal tissues such as gut and pancreas. In both embryos and adult zebrafish livers, tricyclazole disrupted the relationship between oxidant and antioxidant system and resulted in reactive oxygen species (ROS) overload. Meanwhile, it triggered hepatocyte apoptosis and disturbed carbohydrate/lipid metabolism and energy demand systems. These results suggested that tricyclazole could cause severe consequences for vertebrate hepatic development and function.