CHARACTERIZATION OF OVARIAN FOLLICULAR CYSTS AND ASSOCIATED ENDOCRINE PROFILES IN DAIRY-COWS
CHARACTERIZATION OF OVARIAN FOLLICULAR CYSTS AND ASSOCIATED ENDOCRINE PROFILES IN DAIRY-COWS
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DOI：
10.1095/biolreprod53.4.890
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发表时间：
1995-10-01
影响因子：
3.6
通讯作者：
SALFEN, BE
中科院分区：
文献类型：
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作者：
HAMILTON, SA;GARVERICK, HA;SALFEN, BE
一般认为，卵泡囊肿(囊)是一种非排卵性卵泡结构，有助于延长产犊间隔时间。卵泡/囊泡动力学和囊肿病因学尚不清楚。本研究旨在描述卵泡/囊肿的动力学特征，并确定与囊变相关的内分泌变化(病因学)。研究奶牛32头：对照组(n=6)、自发性囊肿组(n=14)和外源性类固醇诱导囊肿组(n=12)。每天对奶牛卵巢进行超声扫描，记录卵泡/囊泡动态变化。采集血液以确定与卵泡/囊泡寿命相关的内分泌变化。观察了囊肿牛的三种卵巢反应：包囊持续、包囊翻转或自然恢复(自愈；包囊翻转并用排卵的卵泡替换)。平均最大囊泡大小(p<；0.05)大于排卵卵泡大小(2.80±0.19比1.60±0.05 cm)。与对照组(8.5+/-0.5天和6-14天)相比，囊肿组从最初检测到卵泡/囊肿波到检测到新的卵泡/囊肿波的平均间隔更长(13.0+/-1.1天；p<；0.05)，且变异性更大(6-26天；p<；0.05)。囊泡的生长速度与卵泡的生长速度相同，但持续生长的时间更长。在检测到所有卵泡/囊肿波之前，FSH出现一过性升高。在排卵周期中，黄体生成素(P<；0.01)和雌二醇-17β(P<；0.05)的浓度在排卵周期中高于排卵周期中的奶牛，大约在波检测到的时候和排卵前后，或者在囊泡达到与排卵的卵泡直径相同的时候。总而言之，包囊和卵泡是动态结构，与正常发情周期的奶牛相比，包囊检测波的间隔时间更长。较高浓度的雌二醇-17β和黄体生成素，而不是卵泡刺激素，与包囊的发展和持久性有关。
It is generally accepted that ovarian follicular cysts (cysts) are nonovulatory follicular structures that contribute to extended calving intervals. Follicle/cyst dynamics and the etiology of cysts are unclear. The present study was conducted to characterize follicle/cyst dynamics and to define endocrine changes (etiology) associated with cyst development. Thirty-two dairy cows were studied: controls (n = 6), cows with spontaneously occurring cysts (n = 14), and cows in which cysts were induced by exogenous steroid treatment (n = 12). Ovaries of cows were scanned daily by ultrasonography to record follicle/cyst dynamics. Blood was collected to determine endocrine changes associated with follicle/cyst life span. Three ovarian responses in cows with cysts were observed: persistence of cysts, turnover of cysts, or spontaneous recovery (self-recovered; turnover of cysts and replacement with a follicle that ovulated). Mean maximum size of cysts was larger (p < 0.05) than that of ovulatory follicles (2.80 +/- 0.19 vs. 1.60 +/- 0.05 cm). Mean interval from initial detection of follicle/ cyst wave to detection of a new follicle/cyst wave in cows with cysts was longer (13.0 +/- 1.1 days; p < 0.05) and more variable (6 to 26 days; p < 0.05) than in controls (8.5 +/- 0.5 days and 6-14 days, respectively). Cysts grew at the same rate as follicles hut continued to grow for an additional period of time. A transient increase in FSH preceded detection of all follicle/cyst waves. Concentrations of LH (p < 0.01) and estradiol-17 beta (p < 0.05) were greater in cows with cysts than in cows in ovulatory cycles around the time of wave detection and around the time of ovulation or at the time when cysts reached a diameter equivalent to that of follicles that ovulated. In conclusion, cysts and follicles are dynamic structures, with cysts having longer intervals between wave detections compared to the interval in cows with normal estrous cycles. Greater concentrations of estradiol-17 beta and LH, but not FSH, were associated with development and persistence of cysts.