Effects of a sedative antihistamine, D‐chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving
Effects of a sedative antihistamine, D‐chlorpheniramine, on regional cerebral perfusion and performance during simulated car driving
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DOI：
10.1002/hup.909
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发表时间：
2008-03
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影响因子：
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通讯作者：
M. Tashiro;Yumiko Sakurada;H. Mochizuki;E. Horikawa;M. Maruyama;N. Okamura;S. Watanuki;H. Arai;M. Itoh;K. Yanai
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文献类型：
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作者：
M. Tashiro;Yumiko Sakurada;H. Mochizuki;E. Horikawa;M. Maruyama;N. Okamura;S. Watanuki;H. Arai;M. Itoh;K. Yanai
抗组胺药物的镇静副作用已被认为在汽车驾驶中具有潜在的危险，但这些效应背后的机制迄今尚未阐明。本研究的目的是在单盲交叉研究设计的基础上，使用正电子发射断层扫描(PET)和[15O]H2O检测在模拟汽车驾驶任务中口服D-氯苯那敏后局部脑血流量(RCBF)的反应。
The sedative side effects of antihistamines have been recognized to be potentially dangerous in car driving, but the mechanism underlying these effects has not yet been elucidated to date. The aim of the present study is to examine regional cerebral blood flow (rCBF) responses during a simulated car‐driving task following oral administration of D‐chlorpheniramine using positron emission tomography (PET) and [15O]H2O, based on a single‐blind cross‐over study‐design.