Maladaptive response of arterial myocytes to chronic exposure to Ca2+ channel blockers.
Maladaptive response of arterial myocytes to chronic exposure to Ca2+ channel blockers.
复制标题
动脉肌细胞对长期暴露于 Ca2 通道阻滞剂的适应不良反应。
DOI：
10.1073/pnas.2011909117
复制
发表时间：
2020
影响因子：
11.1
通讯作者：
Santana,LF
中科院分区：
文献类型：
--
作者：
O'Dwyer,SamanthaC;Navedo,ManuelF;Santana,LF
铅笔和纸在我们的社会中无处不在，并且被广泛用于书写和绘画，因为它们易于使用、成本低廉、易于获取且一次性。然而，它们在新兴的皮肤界面健康监测和干预中的应用仍未得到很好的探索。在此，我们报告了各种基于笔纸的皮肤电子设备，包括生物物理（温度、生物电势）传感器、汗液生化（pH、尿酸、葡萄糖）传感器、热刺激器和湿度能量收集器。在这些设备中，铅笔绘制的石墨图案（或与其他化合物结合）用作导电迹线和传感电极，办公复印纸用作柔性支撑基材。这些设备可以对人体的一系列重要生物物理和生化信号进行实时、连续和高保真监测，包括皮肤温度、心电图、肌电图、α、β和θ节律、瞬时心率、呼吸频率、汗液 pH 值、尿酸和葡萄糖，并提供程序化的热刺激。值得注意的是，记录信号的质量与传统方法测量的信号质量相当。此外，湿度能量收集器是通过在铅笔绘制的电极之间的办公复印纸上创建含氧基团的梯度分布来制备的。一个单体器件 (0.87 cm2) 可在环境湿度下产生高达 480 mV 的持续电压 2 小时以上。此外，还开发了一种自供电皮肤离子电渗透皮给药系统作为皮肤化学干预示例。此外，还探索了基于铅笔纸的天线、带有发光二极管（LED）和电池的二维（2D）和三维（3D）电路、可重构组装和可生物降解电子产品（基于水溶性纸）。
Pencils and papers are ubiquitous in our society and have been widely used for writing and drawing, because they are easy to use, low-cost, widely accessible, and disposable. However, their applications in emerging skin-interfaced health monitoring and interventions are still not well explored. Herein, we report a variety of pencil–paper-based on-skin electronic devices, including biophysical (temperature, biopotential) sensors, sweat biochemical (pH, uric acid, glucose) sensors, thermal stimulators, and humidity energy harvesters. Among these devices, pencil-drawn graphite patterns (or combined with other compounds) serve as conductive traces and sensing electrodes, and office-copy papers work as flexible supporting substrates. The enabled devices can perform real-time, continuous, and high-fidelity monitoring of a range of vital biophysical and biochemical signals from human bodies, including skin temperatures, electrocardiograms, electromyograms, alpha, beta, and theta rhythms, instantaneous heart rates, respiratory rates, and sweat pH, uric acid, and glucose, as well as deliver programmed thermal stimulations. Notably, the qualities of recorded signals are comparable to those measured with conventional methods. Moreover, humidity energy harvesters are prepared by creating a gradient distribution of oxygen-containing groups on office-copy papers between pencil-drawn electrodes. One single-unit device (0.87 cm2) can generate a sustained voltage of up to 480 mV for over 2 h from ambient humidity. Furthermore, a self-powered on-skin iontophoretic transdermal drug-delivery system is developed as an on-skin chemical intervention example. In addition, pencil–paper-based antennas, two-dimensional (2D) and three-dimensional (3D) circuits with light-emitting diodes (LEDs) and batteries, reconfigurable assembly and biodegradable electronics (based on water-soluble papers) are explored.