Changes in Biomarkers Associated with Living Kidney Donation
Changes in Biomarkers Associated with Living Kidney Donation
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DOI：
10.1159/000354312
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发表时间：
2013-01-01
影响因子：
4.2
通讯作者：
Townsend, Raymond R.
中科院分区：
文献类型：
--
作者：
Huan, Yonghong;Kapoor, Shiv;Townsend, Raymond R.
活体供体肾脏与肾移植受者更好的移植和总体生存有关。尽管对于精心挑选的活体捐赠者，活体肾脏捐赠通常被认为是安全的，但对肾脏捐赠可能产生的不良反应的担忧仍然存在，特别是对年轻和高风险的捐赠者。在这项研究中，我们检查了34名健康活体肾脏供者的一组与心血管疾病相关的传统和新型血清生物标志物的变化，这些供者平均年龄+/- SD为40 +/- 10岁，估计捐献前肾小球滤过率（GFR）为86 +/- 10 nnl/min/1.73 m(2)。捐献后6个月，尽管GFR的平均估计值显著下降至60 nnl/nnin/1.73 m，但包括体重指数和血压在内的临床参数没有显著变化(2)。在标记物组中，对称二甲基精氨酸和成纤维细胞生长因子23的水平与基线相比显著增加，这表明活体肾脏捐赠可能导致其他队列中与心血管风险相关的生物标记物的变化。巴塞尔S. Karger股份有限公司版权所有
Living donor kidneys have been associated with better graft and overall survival in kidney transplant recipients. Although a living kidney donation is generally considered safe in carefully selected living donors, concerns of possible adverse effects related to kidney donation remain, especially in younger and high-risk donors. In this study, we examined the changes in a panel of traditional and novel serum biomarkers linked with cardiovascular conditions in a cohort of 34 healthy living kidney donors with a mean age +/- SD of 40 +/- 10 years and estimated predonation glomerular filtration rate (GFR) of 86 +/- 10 nnl/min/1.73 m(2). At 6 months after donation, there were no significant changes in the clinical parameters including body mass index and blood pressure despite a significant decline in the mean estimated GFR to 60 nnl/nnin/1.73 m(2). Among the panel of markers, the levels of symmetric dimethylarginine and fibroblast growth factor 23 increased significantly compared to baseline, suggesting that living kidney donation may result in changes in biomarkers that are associated with cardiovascular risk in other cohorts. Copyright (C) 2013 S. Karger AG, Basel