Experimental squalene adjuvant II.: Harmlessness and local reactogenity
Experimental squalene adjuvant II.: Harmlessness and local reactogenity
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DOI：
10.1016/j.vaccine.2004.02.024
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发表时间：
2004-09-03
期刊：
影响因子：
5.5
通讯作者：
Bajová, V
中科院分区：
文献类型：
--
作者：
Benísek, Z;Süli, J;Bajová, V
对实验室动物（豚鼠）进行模型实验，以测试重复给予基于角鲨烯制备的实验性脂质佐剂（实验性角鲨烯佐剂-ESA）可能产生的过敏反应（致敏可能性）。在用ESA致敏激发的动物和对照动物之间没有观察到显著差异。为了评价局部组织反应性（局部反应原性），也关于施用ESA的过程动力学，在佐剂施用位置进行组织的比较病理解剖学和病理组织学检查。实验结果表明，本实验室制备的脂质佐剂的局部反应性很低。热原试验也证实了ESA的安全性，鲎试剂标示灵敏度λ <0.25 IU/cm（3）。(C)2004爱思唯尔有限公司保留所有权利。
Model experiments on laboratory animals (guinea pigs) were carried out to test the possible allergic reaction (possibility of sensitisation) to the repeated administration of an experimental lipoid adjuvant prepared on the basis of squalene (experimental squalene adjuvant-ESA). No significant differences were observed between the animals sensitised-provoked with ESA and control animals. In order to evaluate the local tissue reactivity (local reactogenity), also with regard to the process dynamics to the administration of ESA, comparative patho-anatomical and patho-histological examinations of tissues were carried out in the location of adjuvant administration. The examinations indicated very low local reactogenity of the experimental lipoid adjuvant prepared in our laboratory. The test of pyrogenicity also confirmed the safety of ESA, the labelled lysate sensitivity lambda was under 0.25 IU/cm(3). (C) 2004 Elsevier Ltd. All rights reserved.