Understanding the impact of hypoglycemia on the cardiovascular system.
Understanding the impact of hypoglycemia on the cardiovascular system.
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DOI：
10.1080/17446651.2017.1275960
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发表时间：
2017
影响因子：
3.2
通讯作者：
Davis SN
中科院分区：
文献类型：
--
作者：
Davis IC;Ahmadizadeh I;Randell J;Younk L;Davis SN
低血糖常见于需要胰岛素的1型或2型糖尿病患者。本文将回顾关于低血糖的促炎和促动脉粥样硬化作用的最新信息。此外，低血糖对心律失常电位和动脉内皮功能障碍的影响也将被讨论。低血糖对1型和2型糖尿病心血管发病率和死亡率的影响也将被回顾。严重低血糖导致死亡和心血管及其他器官系统严重不良事件的相对和绝对风险在最近发表的关于血糖控制和结果的大型临床试验中得到了强调。如果未来的研究可以发展更广泛的终点，包括轻度和中度低血糖，以及更可靠的方法来捕捉与不良事件同时发生的低血糖，这将是有帮助的。此外，考虑将低血糖作为主要结局，可能有助于确定低血糖对心血管疾病发病率和死亡率的可能原因和影响。
Hypoglycemia occurs commonly in insulin requiring individuals with either Type 1 or Type 2 Diabetes. This article will review recent information on the pro-inflammatory and pro-atherothrombotic effects of hypoglycemia. Additionally, effects of hypoglycemia on arrhythmogenic potential and arterial endothelial dysfunction will be discussed. Effects of hypoglycemia on cardiovascular morbidity and mortality from large clinical studies in Type 1 and Type 2 DM will also be reviewed. The relative and absolute risk of severe hypoglycemia leading to death and serious adverse events in both cardiovascular and other organ systems has been highlighted following the publication of recent large clinical trials focused on glucose control and outcomes. It would be helpful if future studies could develop broader end points to include minor and moderate hypoglycemia as well as more robust methods for capturing hypoglycemia contemporaneously with adverse events. In addition, perhaps consideration of including hypoglycemia as a primary outcome, may help identify the possible cause and effect of hypoglycemia on cardiovascular morbidity and mortality.