DYNAMICS OF TUMOR IMAGING WITH GD-DTPA POLYETHYLENE-GLYCOL POLYMERS - DEPENDENCE ON MOLECULAR-WEIGHT
DYNAMICS OF TUMOR IMAGING WITH GD-DTPA POLYETHYLENE-GLYCOL POLYMERS - DEPENDENCE ON MOLECULAR-WEIGHT
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DOI：
10.1002/jmri.1880040337
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发表时间：
1994-05-01
期刊：
影响因子：
--
通讯作者：
SNOW, RA
中科院分区：
文献类型：
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作者：
DESSER, TS;RUBIN, DL;SNOW, RA
在中枢神经系统外的磁共振（MR）成像中，高分子造影剂比可自由扩散的造影剂具有潜在优势。为了确定大分子造影剂的最佳分子量，作者研究了一种新型的大分子造影剂，钆二亚乙基三胺五乙酸聚乙二醇（DTPA-PEG），合成了7种聚合物（平均）分子量范围从10到83 kd。28只兔的大腿V2癌进行T1加权自旋回波成像注射前和注射后5-60分钟和24小时的Gd-DTPA-PEG聚合物或Gd-DTPA在钆剂量为0.1 mmol/kg。在每个时间点获得肿瘤感兴趣区域的测量值以确定对比增强动力学。对于大于20 kd的Gd-DTPA-PEG聚合物，观察到血池增强动力学。小于20 kd的聚合物显示类似于自由扩散剂Gd-DTPA的动力学。在20 kd阈值以上，较小的聚合物的肿瘤增强更快。作者得出结论，21.9 kd Gd-DTPA-PEG聚合物最适合临床MR成像。
Macromolecular contrast media offer potential advantages over freely diffusible agents in magnetic resonance (MR) imaging outside the central nervous system. To identify an optimum molecular weight for macromolecular contrast media, the authors studied a novel macromolecular contrast agent, gadolinium diethylenetriaminepentaacetic acid polyethylene glycol (DTPA-PEG), synthesized in seven polymer (average) molecular weights ranging from 10 to 83 kd. Twenty-eight rabbits bearing V2 carcinoma in thighs underwent T1-weighted spin-echo imaging before injection and 5-60 minutes and 24 hours after injection of the Gd-DTPA-PEG polymers or Gd-DTPA at a gadolinium dose of 0.1 mmol/kg. Tumor region-of-interest measurements were obtained at each time point to determine contrast enhancement dynamics. Blood-pool enhancement dynamics were observed for the Gd-DTPA-PEG polymers larger than 20 kd. Polymers smaller than 20 kd displayed dynamics similar to those of the freely diffusible agent Gd-DTPA. Above the 20 kd threshold, tumor enhancement was more rapid for smaller polymers. The authors conclude that the 21.9-kd Gd-DTPA-PEG polymer is best suited for clinical MR imaging.