ERYTHROCYTE INCORPORATION OF IRON BY 56-DAY-OLD INFANTS FED A FE-58-LABELED SUPPLEMENT
ERYTHROCYTE INCORPORATION OF IRON BY 56-DAY-OLD INFANTS FED A FE-58-LABELED SUPPLEMENT
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DOI：
10.1203/00006450-199509000-00017
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发表时间：
1995-09-01
影响因子：
3.6
通讯作者：
FRANTZ, JA
中科院分区：
文献类型：
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作者：
FOMON, SJ;ZIEGLER, EE;FRANTZ, JA
为了获得母乳喂养的婴儿在生命的最初几个月补充铁的吸收信息，我们确定了红细胞掺入的稳定铁同位素，给予56-d-母乳喂养的婴儿的形式Fe-58标记的维生素铁补充剂。还研究了喂养低铁（约4 mg/L）的乳基配方奶粉的相似年龄的婴儿。在两次喂食之间给予Fe-58标记的维生素铁补充剂。Fe-58给药后14天，母乳喂养婴儿的平均红细胞同位素掺入量为剂量的7.8%，配方奶粉婴儿为剂量的4.4%。与喂养相关的差异具有统计学意义，这可能反映了配方奶粉喂养的婴儿肠道中铁吸收抑制剂的数量更大。对于母乳喂养的婴儿，Fe-58标记的维生素铁补充剂的平均铁摄入量为7.99 mg，红细胞掺入量为剂量的7.8%，相当于0.62 mg，该值在吸收铁的估计需求量范围内。我们的结论是，2个月大的母乳喂养的婴儿能够从铁补充剂中吸收营养显著量的铁。
In an effort to obtain information about absorption of supplemental iron by breast-fed infants during the early months of life, we determined erythrocyte incorporation of a stable iron isotope, administered to 56-d-old breast-fed infants in the form of a Fe-58-labeled vitamin-iron supplement. Infants of similar age fed a milk-based formula low in iron (approximately 4 mg/L) were also studied. The Fe-58-labeled vitamin-iron supplement was given between feedings. Fourteen days after administration of Fe-58, mean erythrocyte incorporation of the isotope was 7.8% of the dose by breast-fed infants and 4.4% of the dose by formulated infants. The feeding-related difference was statistically significant, probably reflecting the greater quantities of inhibitors of iron absorption in the intestines of formula-fed infants. With mean iron intake from the Fe-58-labeled vitamin-iron supplement of 7.99 mg for the breast-fed infants, erythrocyte incorporation of 7.8% of the dose corresponded to 0.62 mg, a value in the range of the estimated requirement for absorbed iron. We conclude that 2-mo-old breast-fed infants are able to absorb nutritionally significant amounts of iron from an iron supplement.