DIET AND PANCREATIC-CANCER - A CASE-CONTROL STUDY
DIET AND PANCREATIC-CANCER - A CASE-CONTROL STUDY
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DOI：
10.1093/oxfordjournals.aje.a114479
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发表时间：
1986-12-01
影响因子：
5
通讯作者：
WIECHEL, KL
中科院分区：
文献类型：
--
作者：
NORELL, SE;AHLBOM, A;WIECHEL, KL
在1982-1984年在瑞典进行的一项以人群为基础的病例对照研究中，作者研究了胰腺癌与几种饮食因素（咖啡、酒精和烟草）的关系。分析基于99例病例、138例人群对照和163例医院对照。这些病例是在斯德哥尔摩和乌普萨拉的三个外科部门被诊断患有胰腺外分泌癌的40-79岁的人。与每个系列的对照相比，风险随着油炸和烧烤肉类的消费频率的增加而增加（例如，与人群对照组相比，每周摄入的相对风险（RR）= 1.7（90%置信区间（CI）= 1.1-2.7），几乎每天摄入的RR = 13.4（90% CI = 2.4-74.7）。此外，发现与其他油炸或烧烤食物有关，但与油炸或烧烤以外的肉类无关。风险也随着人造黄油的摄入而增加（例如，与人群对照组相比，一片面包上15+ g人造黄油的RR = 9.7（90% CI = 3.1-30.2）。相比之下，没有额外的风险与黄油的高摄入量有关。低风险与经常食用水果和蔬菜有关，特别是几乎每天摄入的胡萝卜（RR = 0.3（90% CI = 0.2-0.7））和柑橘类水果（RR = 0.5（90% CI = 0.3-0.9））。没有发现与咖啡，人造甜味剂或酒精消费的一致关联，但每天至少吸一包香烟的风险增加了三倍。
In a population-based case-control study carried out in Sweden in 1982-1984, the authors examined the association of pnacreatic cancer with several dietary factors, coffee, alcohol, and tobacco. Analyses were based on 99 cases, 138 population controls, and 163 hospital controls. The cases were persons aged 40-79 years diagnosed with cancer of the exocrine pancreas at three surgical departments in Stockholm and Uppsala. The risk increased with higher consumption frequency of fried and grilled meat in the comparison with each series of controls (e.g., relative risk (RR) = 1.7 (90% confidence interval (Cl) = 1.1-2.7) for weekly intake and RR = 13.4 (90% Cl = 2.4-74.7) for almost daily intake, in the comparison with population controls). Furthermore, associations were found with other fried or grilled foods, but not with meat other than fried or grilled. The risk also increased with the intake of margarine (e.g., RR = 9.7 (90% Cl = 3.1-30.2) for 15+ g of margarine on a slice of bread, in the comparison with population controls). In contrast, no excess risk was associated with high intake of butter. A low risk was associated with frequent consumption of fruits and vegetables, particularly carrots (RR = 0.3 (90% Cl = 0.2-0.7)) and citrus fruits (RR = 0.5 (90% Cl = 0.3-0.9)) for almost daily intake. No consistent associations were found with coffee, artificial sweeteners or alcohol consumption, but a threefold increase in risk was associated with smoking at least one pack of cigarettes per day.