PNEUMOCYSTIS-CARINII PNEUMONIA IN ZIMBABWE
PNEUMOCYSTIS-CARINII PNEUMONIA IN ZIMBABWE
复制标题
DOI：
10.1016/s0140-6736(95)91862-0
复制
发表时间：
1995-11-11
期刊：
影响因子：
168.9
通讯作者：
MASON, PR
中科院分区：
文献类型：
--
作者：
MALIN, AS;GWANZURA, LKZ;MASON, PR
卡氏肺孢子虫肺炎(PCP)据说在非洲很罕见，据报道，在有呼吸道症状的人类免疫缺陷病毒(HIV)感染者中，发病率为0-22%。在南非一家中心医院的一年多时间里，(音译)对青霉素无效、痰涂片阴性抗酸杆菌的急性弥漫性肺炎患者进行了支气管镜检查。对支气管肺泡灌洗液进行细菌、真菌、卡氏肺孢子虫和分枝杆菌的检测。21名患者(33%)患有PCP，24名患者(39%)患有肺结核；其中6名患者同时患有这两种感染。5例卡波西肉瘤(KS)合并PCP、结核或其他感染，其中1例仅发现KS，21例未发现病原体。使用Logistic回归模型评估临床、放射学和动脉血气预测PCP和肺结核、胸片上细小的网状结节阴影(结节成分)。
Pneumocystis carinii pneumonia (PCP) is said to be rare in Africa, with reported rates of 0-22% in human-immunodeficiency-virus (HIV) infected individuals with respiratory symptoms. Over one year in a central hospital in southern Africa, 64 HIV-infected patients with acute diffuse pneumonia unresponsive to penicillin and sputum smear-negative for acid-fast bacilli underwent fibreoptic bronchoscopy. Bronchoalveolar lavage fluid was assessed for bacteria, fungi, Pneumocystis carinii, and mycobacteria.21 patients (33%) had PCP and 24 (39%) had tuberculosis; 6 of these had both infections. 5 patients had Kaposi's sarcoma (KS) associated with PCP, tuberculosis, or another infection, in 1 patient KS was the only finding, and in 21 no pathogen was identified. A logistic regression model was used to assess clinical, radiographic, and arterial blood gas predictors of PCP and tuberculosis, Fine reticulonodular shadowing on the chest radiograph (nodular component