Bmc Complementary and Alternative Medicine Aqueous Extract of Terminalia Arjuna Prevents Carbon Tetrachloride Induced Hepatic and Renal Disorders
Bmc Complementary and Alternative Medicine Aqueous Extract of Terminalia Arjuna Prevents Carbon Tetrachloride Induced Hepatic and Renal Disorders
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DOI：
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发表时间：
2006
影响因子：
4.6
通讯作者：
Prasenjit Manna;M. Sinha;P. Sil
中科院分区：
文献类型：
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作者：
Prasenjit Manna;M. Sinha;P. Sil
背景资料：四氯化碳（CCl 4）是一种众所周知的肝毒素，已知暴露于这种化学物质会诱导氧化应激，并通过形成自由基引起肝损伤。急性和慢性肾损害也是非常常见的病理生理紊乱引起的四氯化碳。本研究旨在评价印度一种重要的药用植物-阿朱木（Termnalia arjuna，TA）树皮的水提取物对四氯化碳（CCl 4）诱导的小鼠肝脏和肾脏的氧化应激及由此引起的功能障碍的保护作用。
Background: Carbon tetrachloride (CCl 4) is a well-known hepatotoxin and exposure to this chemical is known to induce oxidative stress and causes liver injury by the formation of free radicals. Acute and chronic renal damage are also very common pathophysiologic disturbances caused by CCl 4. The present study has been conducted to evaluate the protective role of the aqueous extract of the bark of Termnalia arjuna (TA), an important Indian medicinal plant widely used in the preparation of ayurvedic formulations, on CCl 4 induced oxidative stress and resultant dysfunction in the livers and kidneys of mice.