Strontium Nitrate Decreased Histamine-Induced Itch Magnitude and Duration in Man
Strontium Nitrate Decreased Histamine-Induced Itch Magnitude and Duration in Man
复制标题
DOI：
10.1159/000018367
复制
发表时间：
2000-05
期刊：
影响因子：
3.4
通讯作者：
H. Zhai;W. Hannon;G. Hahn;R. Harper;A. Pelosi;H. Maibach
中科院分区：
文献类型：
--
作者：
H. Zhai;W. Hannon;G. Hahn;R. Harper;A. Pelosi;H. Maibach
背景：先前的研究已表明锶盐具有强大且广泛的抑制感觉刺激的能力。
目的：为确定局部使用锶盐可能具有的止痒效果，我们进行了一项双盲随机研究，以评估20%硝酸锶对瘙痒程度（强度）和持续时间的影响。
方法：在8名受试者中，将硝酸锶涂抹于前臂掌侧，同时在对侧前臂掌侧涂抹赋形剂作为对照，持续30分钟；然后两种物质再额外涂抹5分钟。之后通过皮内注射组胺来实验性地诱发瘙痒。在最初的20分钟内，每分钟使用视觉模拟量表（VAS）对瘙痒程度进行评分。同时记录以分钟为单位的瘙痒持续时间。
结果：与赋形剂对照相比，硝酸锶显著地将瘙痒持续时间从28.1±5.4分钟（平均值±标准误）缩短至18.5±4.2分钟（p<0.01），并且在12 - 20分钟的时间点以及总体上降低了瘙痒程度（p<0.05）。
结论：硝酸锶可作为一种局部止痒剂，用于减轻组胺介导的瘙痒。
Background: Previous studies have demonstrated that strontium salts have a potent and broad ability to suppress sensory irritation. Objective: To ascertain the possible antipruritic effects of topical strontium salts, we conducted a double-blind randomized study to evaluate the effect of 20% strontium nitrate on itch magnitude (intensity) and duration. Methods: In 8 human subjects, strontium nitrate was applied to the volar forearm and vehicle control to the contralateral volar forearm for 30 min; both substances were reapplied for an additional 5 min. Itch was then experimentally induced by intradermal injection of histamine. Itch magnitude was rated each minute for the first 20 min using a visual analogue scale (VAS). Itch duration in minutes was also recorded. Results: Strontium nitrate, in comparison to its vehicle control, significantly shortened itch duration from 28.1 ± 5.4 min (mean ± SEM) to 18.5 ± 4.2 min (p < 0.01) and reduced itch magnitude at time points 12–20 min and overall (p < 0.05). Conclusion: Strontium nitrate may act as a topical antipruritic agent in reducing histamine-mediated itch.