Multiscale Entropy Analysis of Pulse Wave Velocity for Assessing Atherosclerosis in the Aged and Diabetic
Multiscale Entropy Analysis of Pulse Wave Velocity for Assessing Atherosclerosis in the Aged and Diabetic
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DOI：
10.1109/tbme.2011.2159975
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发表时间：
2011-10-01
影响因子：
4.6
通讯作者：
Tang, Chieh-Ju
中科院分区：
文献类型：
--
作者：
Wu, Hsien-Tsai;Hsu, Po-Chun;Tang, Chieh-Ju
本研究提出了一种基于动态脉搏波速度（PWV）的生物医学参数，用于评估老年人和糖尿病人群的动脉粥样硬化程度。2009年7月至2010年10月期间，从单个医疗机构总共招募了91名受试者。受试者被分为四组：健康青年人（组1，n = 22），健康中老年人（组2，n = 28），血糖控制满意的2型糖尿病患者（组3，n = 21），血糖控制不满意（组4，n = 20）。采用自行研制的6通道心电图PWV设备，在30 min内连续采集1000次PWVfoot值，并对采集的数据进行多尺度熵分析。大规模MSE指数（MEILS）被选为评估参数。MEILS不仅成功区分了第1组和第2组的受试者，而且还显示了第3组和第4组之间的显著差异。与常规参数PWVfoot和MEI在R-R间期[即，MEI（RRI）]在评价动脉粥样硬化病变程度时，动态参数MEILS（PWV）能更好地反映年龄和血糖控制对动脉粥样硬化进展的影响。
This study proposed a dynamic pulse wave velocity (PWV)-based biomedical parameter in assessing the degree of atherosclerosis for the aged and diabetic populations. Totally, 91 subjects were recruited from a single medical institution between July 2009 and October 2010. The subjects were divided into four groups: young healthy adults (Group 1, n = 22), healthy upper middle-aged adults (Group 2, n = 28), type 2 diabetics with satisfactory blood sugar control (Group 3, n = 21), and unsatisfactory blood sugar control (Group 4, n = 20). A self-developed six-channel electrocardiography (ECG)-PWV-based equipment was used to acquire 1000 successive recordings of PWVfoot values within 30 min. The data, thus, obtained were analyzed with multiscale entropy (MSE). Large-scale MSE index (MEILS) was chosen as the assessment parameter. Not only did MEILS successfully differentiate between subjects in Groups 1 and 2, but it also showed a significant difference between Groups 3 and 4. Compared with the conventional parameter of PWVfoot and MEI on R-R interval [i.e., MEI (RRI)] in evaluating the degree of atherosclerotic change, the dynamic parameter, MEILS (PWV), could better reflect the impact of age and blood sugar control on the progression of atherosclerosis.