CDC Recommendations for Hepatitis C Screening Among Adults - United States, 2020
CDC Recommendations for Hepatitis C Screening Among Adults - United States, 2020
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DOI：
10.15585/mmwr.rr6902a1
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发表时间：
2020-04-10
影响因子：
33.7
通讯作者：
Ryerson, A. Blythe
中科院分区：
文献类型：
--
作者：
Schillie, Sarah;Wester, Carolyn;Ryerson, A. Blythe
丙型肝炎病毒（HCV）感染是美国发病率和死亡率的主要来源。 HCV 主要通过肠外接触传染性血液或含有血液的体液传播，最常见的是通过注射吸毒。目前还没有针对丙型肝炎的疫苗，也没有有效的暴露前或暴露后预防措施。超过一半的丙型肝炎病毒感染者会发展为慢性感染。直接作用抗病毒治疗可通过 8-12 周的全口服药物治疗方案使大多数人获得病毒学治愈。本报告补充（即更新和总结）了 CDC 先前发布的有关美国 HCV 感染检测的建议（Smith BD、Morgan RL、Beckett GA 等人。《关于识别 1945-1965 年出生者慢性丙型肝炎病毒感染的建议》。MMWR Recomm Rec 2012；61 [No. RR-4]）。 CDC 正在通过两项新建议补充之前的指导：1) 所有年龄 >= 18 岁的成年人一生中至少进行一次丙型肝炎筛查，HCV 感染流行率较高的地区除外。
Hepatitis C virus (HCV) infection is a major source of morbidity and mortality in the United States. HCV is transmitted primarily through parenteml exposures to infectious blood or body fluids that contain blood most commonly through injection drug use. No vaccine against hepatitis C exists and no effective pre- or postexposure prophylaxis is available. More than half of persons who become infected with HCV will develop chronic infection. Direct-acting antiviral treatment can result in a virologic cure in most persons with 8-12 weeks of all-oral medication regimens. This report augments (i.e., updates and summarizes) previously published recommendations from CDC regarding testing for HCV infection in the United States (Smith BD, Morgan RL, Beckett GA, et al. Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945-1965. MMWR Recomm Rec 2012;61 [No. RR-4]). CDC is augmenting previous guidance with two new recommendations: 1) hepatitis C screening at least once in a lifetime for all adults aged >= 18 years, except in settings where the prevalence of HCV infection is