The structural neural correlates of atypical facial expression recognition in autism spectrum disorder
The structural neural correlates of atypical facial expression recognition in autism spectrum disorder
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DOI：
10.1007/s11682-021-00626-1
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发表时间：
2022-01-20
影响因子：
3.2
通讯作者：
Toichi，Motomi
中科院分区：
文献类型：
--
作者：
Uono，Shota;Sato，Wataru;Toichi，Motomi
先前的研究表明，自闭症谱系障碍（ASD）的个体在识别面部表情方面比典型的发展中（TD）个体更差。本研究采用基于体素的形态测量法（VBM）研究了ASD患者和非ASD患者情绪识别的结构神经相关性差异。我们从27名高功能ASD成年人和27名年龄和性别匹配的TD个体中获得了结构MRI数据。识别面部表情的能力是使用具有六种基本情绪（愤怒、厌恶、恐惧、快乐、悲伤和惊讶）的标签匹配范式来测量的。在控制了智力因素后，行为任务没有发现ASD患者的情绪识别缺陷。然而，对感兴趣区域的VBM分析显示，TD个体的六种基本情绪的平均准确率与右额下回的灰质体积之间存在正相关，但ASD个体则不然。在每种情绪条件下，整个大脑区域的VBM显示，在ASD患者中，厌恶面孔的准确率百分比与左背内侧前额叶皮质的灰质体积呈正相关，但在TD患者中则不然。不同的相关模式表明，患有和没有ASD的个体使用不同的处理机制来识别他人的面部表情。
Previous studies have demonstrated that individuals with autism spectrum disorder (ASD) are worse at recognizing facial expressions than are typically developing (TD) individuals. The present study investigated the differences in structural neural correlates of emotion recognition between individuals with and without ASD using voxel-based morphometry (VBM). We acquired structural MRI data from 27 high-functioning adults with ASD and 27 age- and sex-matched TD individuals. The ability to recognize facial expressions was measured using a label-matching paradigm featuring six basic emotions (anger, disgust, fear, happiness, sadness, and surprise). The behavioural task did not find deficits of emotion recognition in ASD after controlling for intellectual ability. However, the VBM analysis for the region of interest showed a positive correlation between the averaged percent accuracy across six basic emotions and the grey matter volume of the right inferior frontal gyrus in TD individuals, but not in individuals with ASD. The VBM for the whole brain region under each emotion condition revealed a positive correlation between the percent accuracy for disgusted faces and the grey matter volume of the left dorsomedial prefrontal cortex in individuals with ASD, but not in TD individuals. The different pattern of correlations suggests that individuals with and without ASD use different processing mechanisms for recognizing others’ facial expressions.