Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation by emodin derivatives
Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation by emodin derivatives
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DOI：
10.1016/j.canlet.2005.10.043
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发表时间：
2006-09-28
期刊：
影响因子：
9.7
通讯作者：
Tokuda, Harukuni
中科院分区：
文献类型：
--
作者：
Koyama, Junko;Inoue, Munetaka;Tokuda, Harukuni
作为使用天然和合成产物作为癌症化学预防剂的研究的延续，我们使用循环伏安法研究了从大黄素在pH 7.2的磷酸盐缓冲液中制备的羟基化大黄素衍生物的还原-氧化电位。羟基化大黄素衍生物对EB病毒早期抗原活化的抑制作用与羟基化大黄素衍生物的还原电位和羟基数目之间存在显著相关性。电子性质，即9位碳（C-9）和11位氧（O-11）的LUMO能量和原子电荷，也可能有助于估计对EBV-EA激活的抑制作用。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction-oxidation potentials of hydroxylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2 using cyclic voltammetry. A significant correlation was found between the reduction potentials and number of the hydroxyl groups and the inhibitory effects of the hydroxylated emodin derivatives on Epstein-Barr virus early antigen activation. The electronic properties, i.e. LUMO energy and atomic charges of carbon at the 9-position (C-9) and oxygen at the 11-position (O-11), may also be useful for estimating the inhibitory effect on EBV-EA activation. (c) 2006 Elsevier Ireland Ltd. All rights reserved.