Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, notch, and bone morphogenic proteins
Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, notch, and bone morphogenic proteins
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DOI：
10.1002/jcb.21509
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发表时间：
2007-11-01
影响因子：
4
通讯作者：
Hollingsworth, Michael A.
中科院分区：
文献类型：
--
作者：
Bailey, Jennifer M.;Singh, Pankaj K.;Hollingsworth, Michael A.
这篇综述将强调发育生物学中三个关键途径的重要性，以及我们对它们在调节肿瘤转移中的作用的新认识：骨形态发生蛋白（BMP）、Notch 和 Sonic hedgehog（SHH）。我们将讨论它们在发育中的已知作用之间的相似之处，以及肿瘤细胞如何利用这些过程来创建增强肿瘤转移的微环境。肿瘤细胞侵占对胚胎发育至关重要的途径并不奇怪，因为许多正常发育程序包括在肿瘤进展为转移表型期间也可见的过程，包括上皮细胞向间质转化（EMT）、组织特异性形态发生、细胞运动和侵袭。 BMP 参与 EMT，有助于组织特异性形态发生，并在高度转移的肿瘤细胞中表达。 BMP 也被假设在肿瘤前生态位的建立中发挥作用。 Notch 和 SHH 促进新血管形成、血管生成、EMT，并有助于维持高度转移的肿瘤干细胞。
This review will highlight the significance of three critical pathways in developmental biology and our emerging understanding of their roles in regulating tumor metastasis: Bone morphogenic protein (BMP), Notch and Sonic hedgehog (SHH). We will discuss parallels between their known roles in development and how these processes can be used by tumor cells to create microenvironments that enhance tumor metastasis. That tumor cells usurp pathways critical to the developing embryo is not surprising, as many of the normal developmental programs include processes that are also seen during tumor progression to a metastatic phenotype, including epithelia] to mesenchymal transition (EMT), tissue specific morphogenesis, cellular motility and invasion. BMPs are involved in EMT, contribute to tissue specific morphogenesis, and are expressed in highly-metastatic tumor cells. BMPs have also been hypothesized to have a role in the establishment of a pre-neoplastic niche. Notch and SHH facilitate neovascularization, angiogenesis, EMT and can contribute to the maintenance of highly-metastatic tumor stem cells.