Effect of carnitine on size limitation of experimental myocardial infarct.
Effect of carnitine on size limitation of experimental myocardial infarct.
复制标题
肉碱对实验性心肌梗塞大小限制的影响。
DOI：
10.11501/3086197
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
I. Sakurai
中科院分区：
文献类型：
--
作者：
K. Ura;Y. Hironaka;I. Sakurai
为了阐明1-肉毒碱氯化物对缺血心肌的影响，以挽救犬心肌梗死坏死周围危险区的可能性，在冠状动脉结扎后20小时，通过使用单星蓝和组织脱氢酶组织化学进行大小检测，对心肌梗死的程度进行定量评价。结果显示，对照组中未挽救的梗塞区与闭塞的冠状动脉床的比率为85.3 +/-2.9%，而1-肉毒碱给药（1C）组中为53.2 +/-3.6%。这些比值之间的差异具有统计学显著性（p <0.01）。结果还表明血清CPK浓度显著降低。因此，肉毒碱可能通过改善危险区心肌细胞的脂质代谢，特别是脂肪酸代谢的改变，在防止梗死面积扩大中发挥作用。
To elucidate 1-carnitine chloride effects ischemic myocardium for the possibility of a salvage of risk zone around necrosis in myocardial infarcts of dogs, a quantitative evaluation of the extent of myocardial infarcts was done by size detection with use of monastral blue and tissue dehydrogenase histochemistry at 20 hours after coronary ligation. The results show that the ratio of unsalvaged infarct zone to occluded coronary bed is 85.3 +/- 2.9% in the control group, while it is 53.2 +/- 3.6% in the 1-carnitine administered (1 C) group. The difference between these ratios is statistically significant (p less than 0.01). The results also indicate significantly lower serum CPK concentration. Therefore, carnitine may play a role in preventing a size extention of infarcts through improving an altered lipid metabolism, particularly a fatty acid metabolism, of myocardial cells in the risk zone.