Multiple boli arterial spin labeling for high signal-to-noise rodent brain perfusion imaging.
Multiple boli arterial spin labeling for high signal-to-noise rodent brain perfusion imaging.
复制标题
用于高信噪比啮齿动物脑灌注成像的多玻利动脉自旋标记。
DOI：
10.1002/mrm.26706
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发表时间：
2018
影响因子：
3.3
通讯作者：
Vallatos A
中科院分区：
文献类型：
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作者：
Vallatos A
目的提出了一种系统的方法来优化一种有前途的临床前动脉自旋标记（ASL）序列，该序列基于一系列绝热射频脉冲标记连续的血水波。方法采用小鼠和大鼠脑成像实验对该序列进行优化和评价。它涉及几个参数的研究，从绝热脉冲的数量和标记持续时间到绝热双曲割线脉冲的性质（即振幅和频率调制）。结果确定了物种依赖参数，允许引入稳健的快速优化协议。与目前ASL研究（278 mm−3小鼠和172 mm−3大鼠）相比，优化后的多boli ASL （mbASL）序列提供了更高的平均每体素信噪比（SNR）。与常用的流动敏感交替反演恢复技术（FAIR）相比，mbASL - to - FAIR的信噪比在小鼠和大鼠中分别达到203%和725%。结论经过适当优化，mbASL可以为啮齿动物脑灌注研究提供可靠的、高信噪比的ASL替代方案。医学杂志79:1020-1030,2018。©2017国际医学磁共振学会。
PurposeA systematic method is proposed for optimizing a promising preclinical arterial spin labeling (ASL) sequence based on the use of a train of adiabatic radiofrequency pulses labeling successive boli of blood water.MethodsThe sequence optimization is performed and evaluated using brain imaging experiments in mice and in rats. It involves the investigation of several parameters, ranging from the number of adiabatic pulses and labeling duration to the properties of the adiabatic hyperbolic secant pulses (ie, amplitude and frequency modulation).ResultsSpecies‐dependent parameters are identified, allowing for robust fast optimization protocols to be introduced. The resulting optimized multiple boli ASL (mbASL) sequence provides with significantly higher average signal‐to‐noise ratios (SNR) per voxel volume than currently encountered in ASL studies (278 mm−3in mice and 172 mm−3in rats). Comparing with the commonly used flow‐sensitive alternating inversion recovery technique (FAIR), mbASL‐to‐FAIR SNR ratios reach 203% for mice and 725% for rats.ConclusionWhen properly optimized, mbASL can offer a robust, high SNR ASL alternative for rodent brain perfusion studies Magn Reson Med 79:1020–1030, 2018. © 2017 International Society for Magnetic Resonance in Medicine.