Intrauterine infection, preterm labor, and cytokines.
Intrauterine infection, preterm labor, and cytokines.
复制标题
宫内感染、早产和细胞因子。
DOI：
10.1016/j.jsgi.2005.09.001
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Espinoza,Jimmy
中科院分区：
文献类型：
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作者：
Romero,Roberto;Erez,Offer;Espinoza,Jimmy
罗伯托·罗梅罗医学博士提供马里兰州埃雷兹和吉米·埃斯皮诺萨医学博士的再出生是全球围产儿发病率和死亡率的主要原因。自发性早产，绒毛膜完整或破裂，占所有早产儿的三分之二。据估计，仅在美国，早产每年给社会造成的损失约为200亿美元。1直到最近，早产被认为是由于分娩的共同途径的组成部分的即时性激活所致：子宫肌层收缩、宫颈撕裂和/或蜕膜激活。2‘3因此，许多研究人员认为，了解足月正常分娩的机制将导致治疗和预防早产/分娩的方法。这一范式并没有实现它的承诺，因为对分娩生理的解释已经被证明比反解放要复杂得多，4 17现在很明显，早产不是简单的“提前分娩”。4早产现在被认为是一种综合征，由能够激活分娩共同终末路径的多个病理过程引起。
Roberto Romero, MD, Offer Erez, MD, and Jimmy Espinoza, MD reterm birth is the leading cause of perinatal morbidity and mortality worldwide. Spontaneous preterm labor, with intact or rupture of the chorioamniotic mem-branes, is responsible for two-thirds of all preterm births. The cost of preterm birth to society is estimated to be approxi-mately $20 billion per year in the United States alone. 1 Until recently, preterm labor was considered to result from extemporaneous activation of the components ofthe common pathway of parturition: myometrial contractility, cervical rip-ening, and/or decidual activation. 2'3 Therefore, many investi gators believed that understanding the mechanisms responsible for normal parturition at term would lead to methods to treat and prevent preterm labor/delivery. This paradigm has not fulfilled its promise, as elucidation of the physiology of partu-rition has proven to be far more complex than anti-cipated4 17 and it is now apparent that preterm labor is not simply" labor before its time." 4 Preterm parturition is now considered a syndrome caused by multiple pathologic processes able to activate the common terminal pathway of parturition.