Lamina-dependent calibrated BOLD response in human primary motor cortex
Lamina-dependent calibrated BOLD response in human primary motor cortex
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DOI：
10.1016/j.neuroimage.2016.06.030
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发表时间：
2016-11-01
期刊：
影响因子：
5.7
通讯作者：
Moeller, Harald E.
中科院分区：
文献类型：
--
作者：
Guidi, Maria;Huber, Laurentius;Moeller, Harald E.
最近，在功能任务期间解开不同皮质深度的神经活动引起了越来越多的兴趣，因为这将允许分离前馈和反馈活动。到目前为止，大多数层依赖性研究都依赖于梯度回忆回波 (GRE) 血氧水平依赖性 (BOLD) 采集，这些采集侧重于皮质表面的大引流静脉。目前的研究旨在在层流尺度上获得初级运动皮层的定量脑活动反应，而不会由于伴随的继发性血管效应而受到污染。使用戴维斯模型评估诱发氧化代谢，以研究其在层流依赖性功能磁共振成像中的适用性、优点和局限性。在单侧手指敲击任务期间，校准参数 M 和脑耗氧代谢率 (CMRO2) 变化的平均值分别为 (11 +/- 2)% 和 (30 +/- 7)%，在整个皮质深度上具有明显的变化特征。这里提出的结果表明，基于 BOLD 的功能磁共振成像 (fMRI) 与整个皮质深度的代谢变化之间存在解耦，而 CMRO2 和 CBV 之间的紧密耦合在整个皮质层中保持不变。我们的结论是，戴维斯模型可以帮助获得层板依赖性代谢变化的估计，而不会受到大引流静脉的污染，并且在参与者之间具有高度的一致性和可重复性。 (C) 2016 Elsevier Inc. 保留所有权利。
Disentangling neural activity at different cortical depths during a functional task has recently generated growing interest, since this would allow to separate feedforward and feedback activity. The majority of layer-dependent studies have, so far, relied on gradient-recalled echo (GRE) blood-oxygenation-level dependent (BOLD) acquisitions, which are weighted towards the large draining veins at the cortical surface. The current study aims to obtain quantitative brain activity responses in the primary motor cortex on a laminar scale without the contamination due to accompanying secondary vascular effects.Evoked oxidative metabolism was evaluated using the Davis model, to investigate its applicability, advantages, and limits in lamina-dependent fMRI. Average values for the calibration parameter, M, and for changes in the cerebral metabolic rate of oxygen consumption (CMRO2) during a unilateral finger-tapping task were (11 +/- 2)% and (30 +/- 7)%, respectively, with distinct variation features across the cortical depth. The results presented here showed an uncoupling between BOLD-based functional magnetic resonance imaging (fMRI) and metabolic changes across cortical depth, while the tight coupling between CMRO2 and CBV was conserved across cortical layers. We conclude that the Davis model can help to obtain estimates of lamina-dependent metabolic changes without contamination from large draining veins, with high consistency and reproducibility across participants. (C) 2016 Elsevier Inc. All rights reserved.