Dendritic cells and CD4+ CD25+ T regulatory cells:: Crosstalk between two professionals in immunity versus tolerance
Dendritic cells and CD4+ CD25+ T regulatory cells:: Crosstalk between two professionals in immunity versus tolerance
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DOI：
10.2741/1889
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发表时间：
2006-05-01
影响因子：
3.1
通讯作者：
Chen, WJ
中科院分区：
文献类型：
--
作者：
Chen, WJ
树突状细胞(DC)是一种专职的抗原提呈细胞(APC)。CD4(+)CD25(+)T调节细胞(T Regs)是公认的专业调节细胞。DC不仅通过特异性抗原的摄取、加工和递呈来启动T细胞免疫，而且通过T细胞的缺失和/或调节性T细胞的诱导来诱导免疫耐受。CD4(+)CD25(+)T调节细胞通过抑制CD4(+)和CD8(+)T细胞、B细胞、巨噬细胞、DC和NK细胞的功能来维持免疫耐受。如果没有树突状细胞和CD4(+)CD25(+)T细胞之间的串扰，免疫和耐受性之间的微妙平衡是不可想象的。本文就树突状细胞和CD4(+)CD25(+)T细胞在免疫耐受中的研究进展作一综述，其中转化生长因子-β(TGF-β)可能是连接这两类细胞的纽带。
Dendritic cells (DCs) are professional antigen presenting cells (APCs). CD4(+)CD25(+) T regulatory cells (T regs) are recognized as professional regulatory cells. DCs not only initiate T cell immunity by uptake, processing and presentation of specific antigens, but also induce immune tolerance by deletion of T cells and/or induction of regulatory T cells. CD4(+)CD25(+) T regs maintain immune tolerance by suppressing the function of CD4(+) and CD8(+) T cells, B cells, macrophages, DCs and NK cells. It would be inconceivable that the delicate balance between immunity and tolerance could be kept impeccable without the crosstalk between DCs and CD4(+)CD25(+) T regs. This review focuses on the recent development in our understanding of DCs and CD4(+)CD25(+) T regs in immune tolerance, with transforming growth factor-beta (TGF-beta) serving as a potential link between these two professionals.