Serum NT-proBNP levels and histopathological myocardial fibrosis in autopsied cases from a Japanese community: The Hisayama Study
Serum NT-proBNP levels and histopathological myocardial fibrosis in autopsied cases from a Japanese community: The Hisayama Study
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日本社区尸检病例中的血清 NT-proBNP 水平和组织病理学心肌纤维化：久山研究
DOI：
10.1016/j.jjcc.2021.03.014
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发表时间：
2021
影响因子：
2.5
通讯作者：
Ninomiya Toshiharu
中科院分区：
文献类型：
--
作者：
Sasaki Takaya;Izumaru Kensuke;Hata Jun;Sakata Satoko;Oishi Emi;Nagata Takuya;Tsuboi Nobuo;Oda Yoshinao;Kitazono Takanari;Yokoo Takashi;Ninomiya Toshiharu
背景利钠肽与动物模型和心脏病患者的心肌纤维化有关.然而，目前尚不清楚血清N末端B型肽原（NT-proBNP）水平是否与无明显心脏病的个体中组织病理学证实的心肌纤维化相关。本研究的目的是评估血清NT-proBNP水平与心肌纤维化面积的关系，方法我们选择了63例无明显心脏病且死亡前6年内有血清NT-proBNP浓度数据的患者，（平均年龄：82岁;男性：52%）来自社区的尸检病例，并评估来自每个病例的四个心脏节段（即总共252个心脏节段）中心肌纤维化的百分比面积。结果血清NT-proBNP水平与心肌纤维化面积呈正相关[Pearson相关系数：r= 0.49（95%可信区间：0.28-0.66），p<0.001]。校正潜在混杂因素后，血清NT-proBNP水平与心肌纤维化面积百分比显著相关。有和没有降低估计肾小球滤过率（<60 mL/min/1.73 m2）的亚组之间的相关性没有异质性的证据Conclusionsthe目前的研究表明，血清NT-proBNP水平升高与心肌纤维化面积的组织病理学测量的尸体解剖的情况下，从社区。这些发现可能有助于阐明血清NT-proBNP水平升高与心肌纤维化之间的关系及其对预后的影响。
Backgroundnatriuretic peptide is associated with myocardial fibrosis in animal models and among patients with heart disease. However, it remains unclear whether serum N-terminal pro-B-type peptide (NT-proBNP) levels are associated with histopathologically proven myocardial fibrosis among individuals without apparent heart disease. This study aimed to evaluate the association between serum NT-proBNP levels and the histopathologically estimated myocardial fibrotic area in autopsied samples from a community.Methodswe selected 63 cases without apparent heart disease with available data of serum NT-proBNP concentrations within six years before death (average age: 82 years; male: 52%) from autopsied cases in a community, and evaluated the percentage areas of myocardial fibrosis in four cardiac segments from each case (i.e. 252 cardiac segments in total). The association between serum NT-proBNP levels and the percentage area of myocardial fibrosis was estimated using a linear mixed model for repeated measures.Resultsserum NT-proBNP levels were positively correlated with myocardial fibrotic area [Pearson's correlation coefficient:r= 0.49 (95% confidence interval: 0.28–0.66),p<0.001]. Serum NT-proBNP levels were significantly associated with the percentage areas of myocardial fibrosis after adjusting for potential confounding factors. There was no evidence of heterogeneity in the association between the subgroups with and without reduced estimated glomerular filtration rate (<60 mL/min/1.73 m2).Conclusionsthe present study demonstrated that elevated serum NT-proBNP levels were associated with the histopathologically measured myocardial fibrotic area in autopsied cases from a community. These findings may help clarify the association between elevated serum NT-proBNP levels and myocardial fibrosis and their influence on prognosis.