Challenges in the successful control of the avian coccidia
Challenges in the successful control of the avian coccidia
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DOI：
10.1016/j.vaccine.2006.12.030
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发表时间：
2007-07-26
期刊：
影响因子：
5.5
通讯作者：
Blake, Darner P.
中科院分区：
文献类型：
--
作者：
Shirley, Martin W.;Smith, Adrian L.;Blake, Darner P.
艾美耳球虫以宿主特异性方式感染牲畜，是球虫病的病因。控制艾美耳球虫属至关重要，目前主要以化疗为主；使用活野生型或减毒寄生虫制剂进行疫苗接种成为越来越多的选择。新一代亚单位、活载体或 DNA 疫苗接种策略正在寻求中，但确定合适抗原的身份仍然很困难。简要讨论了过去和现在控制禽球虫的一些方法，并描述了识别免疫保护性抗原作为候选疫苗的新方法的进展。 (c) 2006 Elsevier Ltd. 保留所有权利。
Eimeria species infect livestock in a host-specific manner and are the cause of the disease, coccidiosis. Control of Eimeria species is essential and is currently dominated by chemotherapy; with vaccination using formulations of live wild-type or attenuated parasites an increasing option. A new generation of subunit, live-vector or DNA vaccination strategies is being sought and determining the identity of suitable antigens remains difficult. Some past and present methods of controlling avian coccidia are discussed briefly and we describe progress with a novel approach to identify immunoprotective antigens as vaccine candidates. (c) 2006 Elsevier Ltd. All rights reserved.