A PROSPECTIVE-STUDY OF BODY-MASS, HEIGHT, AND SMOKING ON THE RISK OF COLORECTAL-CANCER IN WOMEN
A PROSPECTIVE-STUDY OF BODY-MASS, HEIGHT, AND SMOKING ON THE RISK OF COLORECTAL-CANCER IN WOMEN
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DOI：
10.1007/bf00053131
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发表时间：
1991-03-01
影响因子：
2.3
通讯作者：
SPEIZER, FE
中科院分区：
文献类型：
--
作者：
CHUTE, CG;WILLETT, WC;SPEIZER, FE
1976年，美国注册女护士回答了一份关于身高、体重和吸烟史的调查问卷，并在1984年5月之前对结肠癌或直肠癌的发展进行了随访。 在1976年118，404名无癌症的受访者中，在916，170人年的随访中观察到191例结肠癌和49例直肠癌。 在忽略了体重报告后两年内确诊的病例后，我们发现体重与体重的总体关系不大（Quetelet）指数与结肠癌风险相关;然而，体重指数最重的类别提示风险升高（大于或等于29 kg/m2，相对风险（RR）= 1.5; 95%置信区间= 0.8-2.7）相对于最低类别< 21 kg/m2）。 青少年时期自我报告的体重指数与结肠癌风险的相关性略显着，尽管不显着。 身高增加与结肠癌显著相关（RR = 1.6，最高类别[大于或等于168 cm]与最短类别[< 160 cm]的95%置信区间= 1.1-2.5，趋势P = 0.04）。 目前或过去吸烟的措施未能证明与结肠癌有任何一致的关系。
Female registered nurses in the United States who responded to a questionnaire in 1976 that inquired about height, weight, and smoking history were followed for the development of colon or rectal cancers through May of 1984. Among the 118,404 respondents free of cancer in 1976, 191 colon cancers and 49 rectal cancers were observed during 916,170 person-years of follow-up. After omitting cases diagnosed within two years of weight report, we found little overall relation of body mass (Quetelet's) index to colon cancer risk; however there was a suggestion of elevated risk for the heaviest category of body mass index (greater-than-or-equal-to 29 kg/m2, relative risk (RR) = 1.5; 95 percent confidence interval = 0.8-2.7) relative to the lowest category < 21 kg/m2). Self-reported body mass index from adolescence had a slightly more pronounced, although not significant, association with risk of colon cancer. Increasing height was significantly associated with colon cancer (RR = 1.6, 95 percent confidence interval = 1.1-2.5 for the tallest category [greater-than-or-equal-to 168 cm] vs the shortest [< 160 cm], trend P = 0.04). Measures of current or past smoking failed to demonstrate any consistent relationship with colon cancer.