An Analysis of the Duration of Fentanyl and Its Metabolites in Urine and Saliva
An Analysis of the Duration of Fentanyl and Its Metabolites in Urine and Saliva
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DOI：
10.1213/00000539-199303000-00030
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发表时间：
1993-03
影响因子：
5.7
通讯作者：
J. Silverstein;M. Rieders;M. McMullin;S. Schulman;K. Zahl
中科院分区：
文献类型：
--
作者：
J. Silverstein;M. Rieders;M. McMullin;S. Schulman;K. Zahl
本研究旨在确定芬太尼的代谢物是否可用于检测和监测药物滥用。研究了7名接受小剂量（110 ±56 μg）芬太尼给药的女性患者尿液和唾液中芬太尼及其两种代谢产物的存在，研究时间为给药后96 h。从样品中提取芬太尼及其两种代谢产物（去甲芬太尼和去丙酰芬太尼），并通过气相色谱/质谱法进行分析。所有患者术后即刻和24 h时尿中均检测到原型芬太尼，7例患者中有3例检测到原型芬太尼。到72小时，芬太尼检测不到。术后即刻，去甲芬太尼的量大于芬太尼，在48 h时在所有患者中检测到，在96 h时在7例患者中的4例中检测到。在所有检测的尿液标本中均未检出去丙酰芬太尼。芬太尼及其代谢产物在唾液中的任何时间都无法持续检测到。根据这项研究，唾液检测似乎不是尿液检测的可行替代方法。尿中的去甲芬太尼可能被认为是芬太尼滥用测试时的选择。
This study was undertaken to determine if metabolites of fentanyl might be useful in the detection and monitoring of substance abuse. The presence of fentanyl and two of its metabolites in the urine and saliva of seven female patients receiving small doses (110 ±56 μg) of fentanyl was studied up to 96 h from the time of administration. Fentanyl and its two metabolites (norfentanyl and despropionylfentanyl) were extracted from samples and analyzed by gas chromatography/mass spectrometry. Unchanged fentanyl was detectable in urine in all patients immediately postoperatively and in 3 of 7 patients at 24 h. By 72 h, fentanyl was undetectable. Norfentanyl was present in larger quantities than fentanyl immediately postoperatively and was detected in all patients at 48 h and in 4 of 7 patients at 96 h. Despropionylfentanyl was not detected in any of the urine specimens tested. Neither fentanyl nor its metabolites could be detected consistently at any time in saliva. Saliva testing does not appear to be a viable alternative to urine testing based on this study. Urinary norfentanyl might be considered as the substance of choice when testing for fentanyl abuse.