Maternal Filarial Infection Influences the Development of Regulatory T Cells in Children from Infancy to Early Childhood
Maternal Filarial Infection Influences the Development of Regulatory T Cells in Children from Infancy to Early Childhood
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DOI：
10.1371/journal.pntd.0005144
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发表时间：
2016-11-01
影响因子：
3.8
通讯作者：
Satapathy, Ashok K.
中科院分区：
文献类型：
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作者：
Bal, Madhusmita;Ranjit, Manoranjan;Satapathy, Ashok K.
背景感染丝虫病母亲所生的孩子比未感染丝虫病母亲所生的孩子更容易感染丝虫病。但儿童早期感染易感性增加的机制尚不完全清楚。一些研究表明，活动性丝虫感染与调节性T细胞(Tregs)介导的T细胞低反应性有关。由于Tregs在人类胚胎早期由CD4+CD25(Hi)胸腺细胞发育而来，因此可以推测，孕期母体感染不仅影响儿童出生时的Tregs发育，也影响儿童早期Tregs的发育。因此，本研究旨在通过在印度奥迪萨丝虫病流行区选择一群怀孕的母亲及其随后出生的孩子来检验这一假设。方法和主要发现在微丝虫病(MF)发病率下降到
BackgroundChildren born from filarial infected mothers are comparatively more susceptible to filarial infection than the children born to uninfected mothers. But the mechanism of such increased susceptibility to infection in early childhood is not exactly known. Several studies have shown the association of active filarial infection with T cell hypo-responsiveness which is mediated by regulatory T cells (Tregs). Since the Tregs develop in the thymus from CD4+ CD25(hi) thymocytes at an early stage of the human fetus, it can be hypothesized that the maternal infection during pregnancy affects the development of Tregs in children at birth as well as early childhood. Hence the present study was designed to test the hypothesis by selecting a cohort of pregnant mothers and children born to them subsequently in a filarial endemic area of Odisha, India.Methodology and Principal findingA total number of 49 pregnant mothers and children born to them subsequently have been followed up (mean duration 4.4 years) in an area where the microfilariae (Mf) rate has come down to