Unprotected anal intercourse and substance use among men who have sex with men with recent HIV infection
Unprotected anal intercourse and substance use among men who have sex with men with recent HIV infection
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DOI：
10.1097/01.qai.0000230530.02212.86
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发表时间：
2006-11-01
影响因子：
3.6
通讯作者：
Gorbach, Pamina M.
中科院分区：
文献类型：
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作者：
Drumright, Lydia N.;Little, Susan J.;Gorbach, Pamina M.
目的：研究近期感染艾滋病毒的男男性行为者（NISM）药物使用与无保护肛交（UAI）之间的学科内、学科间和学科内关联。方法：194例新近感染艾滋病病毒的男男性接触者与前3位性伴侣完成了一份计算机辅助的性行为和药物使用问卷。使用条件逻辑回归（CLR）来评估116名报告UAI的男男性行为者与部分但不是全部伴侣之间的关联，并使用广义线性混合效应模型（glmm）来评估整个样本中受试者内部和受试者之间的关联（N = 194）。结果：在多变量CLR模型和glmm中，当与主要伴侣一起使用时，UAI与甲基苯丙胺（比值比[OR]分别为4.9和3.5）、大麻（比值比[OR]分别为4.0和2.2）和勃起功能障碍药物（EDMs）的使用相关（比值比分别为13.8和10.1）。结论：结果表明特定物质与UAI之间可能存在直接关联，并提供证据表明甲基苯丙胺和edm的使用可能有助于艾滋病毒的传播。
Objectives: To examine within-subjects and combined between-and within-subjects associations between substance use and unprotected anal intercourse (UAI) among men who have sex with men (NISM) with recent HIV infection.Methods: One hundred ninety-four MSM who were recently infected with HIV completed a computer-assisted questionnaire regarding sexual behaviors and substance use with their last 3 partners. Associations between UAI and substance use were assessed using conditional logistic regression (CLR) to assess associations among the 116 MSM reporting UAI with some but not all partners and generalized linear mixed effects models (GLMMs) to examine a combination of within- and between-subjects associations in the entire sample (N = 194).Results: In multivariate CLR models and GLMMs, UAI was associated with the use of methamphetamine (odds ratio [OR] 4.9 and OR = 3.5, respectively), marijuana (OR = 4.0 and OR 2.2, respectively) and erectile dysfunction medications (EDMs) when used with a main partner (OR 13.8 and OR = 10.1, respectively).Conclusions: Results indicate that a direct association may exist between specific substances and UAI and provide evidence that the use of methamphetamine and EDMs may contribute to HIV transmission.