Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case-Control Study from the Norwegian Breast Cancer Screening Program
Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case-Control Study from the Norwegian Breast Cancer Screening Program
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DOI：
10.1158/1055-9965.epi-17-0611
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发表时间：
2017-12-01
影响因子：
3.8
通讯作者：
Ursin, Giske
中科院分区：
文献类型：
--
作者：
Ellingjord-Dale, Merete;Vosl, Linda;Ursin, Giske
背景：酒精、吸烟和体力活动在多大程度上与乳腺癌的各种亚型相关尚不清楚。我们利用了一个大的人群为基础的筛查队列，以确定这些危险因素是否也增加了预后不良subtypes.Methods的风险：我们进行了匹配的病例对照研究嵌套在挪威乳腺癌筛查计划在2006-2014年。共确定了4，402例乳腺癌病例的风险因素和受体数据。五个对照组与每个病例的出生年份和筛查年份相匹配。使用条件逻辑回归来估计调整潜在混杂因素后的乳腺癌亚型的OR。结果：有2，761例腔A样、709例腔B样HER 2阴性、367例腔B样HER 2阳性、204例HER 2阳性和361例三阴性癌症。目前饮酒与乳腺癌风险总体相关[OR 1.26; 95%置信区间（CI），1.09-1.45]，比较每周6杯以上与从不饮酒者。然而，这种风险增加仅见于管腔A样乳腺癌。每天吸烟20支以上与总体OR为1.41（95% CI，1.06-1.89）相关，管腔A样和管腔B样HER 2阴性癌症具有显著趋势。目前的体力活动（4+小时/周相比，没有）与15%的风险降低管腔A型乳腺癌，但不清楚与其他subtypes.Conclusions：在这项大型研究中，酒精，吸烟，体力活动主要与管腔A型乳腺癌。(C)2017年AACR。
Background: To what extent alcohol, smoking, and physical activity are associated with the various subtypes of breast cancer is not clear. We took advantage of a large population-based screening cohort to determine whether these risk factors also increase the risk of the poor prognosis subtypes.Methods: We conducted a matched case-control study nested within the Norwegian Breast Cancer Screening Program during 2006-2014. A total of 4,402 breast cancer cases with risk factor and receptor data were identified. Five controls were matched to each case on year of birth and year of screening. Conditional logistic regression was used to estimate ORs of breast cancer subtypes adjusted for potential confounders.Results: There were 2,761 luminal A-like, 709 luminal B-like HER2-negative, 367 luminal B-like HER2-positive, 204 HER2-positive, and 361 triple-negative cancers. Current alcohol con-sumption was associated with breast cancer risk overall [OR 1.26; 95% confidence interval (CI), 1.09-1.45] comparing 6+ glasses a week to never drinkers. However, this risk increase was found only for luminal A-like breast cancer. Smoking 20+ cigarettes a day was associated with an OR of 1.41 (95% CI, 1.06-1.89) overall, with significant trends for luminal A-like and luminal B-like HER2-negative cancer. Current physical activity (4+ hours/week compared with none) was associated with 15% decreased risk of luminal A-like cancer, but not clearly with other subtypes.Conclusions: In this large study, alcohol, smoking, and physical activity were predominantly associated with luminal A-like breast cancer.Impact: Alcohol, smoking, and physical activity were associated with luminal A-like breast cancer subtype. (C) 2017 AACR.