Neuroprotection in glaucoma: a model for neuroprotection in optic neuropathies.
Neuroprotection in glaucoma: a model for neuroprotection in optic neuropathies.
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DOI：
10.1097/00055735-200312000-00006
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发表时间：
2003-12-01
影响因子：
3.7
通讯作者：
Katz, Barrett
中科院分区：
文献类型：
--
作者：
Marcic, Tania Sibila;Belyea, David Anthony;Katz, Barrett
综述目的：发现可能对中枢神经系统细胞进行成功的神经抢救、神经恢复和神经保护的模式和病理生理学的努力集中在影响中枢神经系统本身（即大脑）的过程上。在寻找神经保护的过程中经常被忽视的事实是，哺乳动物视神经在许多方面都是中枢神经系统的一个组成部分。因此，眼睛（视神经和视网膜）为神经保护和神经保护剂提供了理想的临床模型。青光眼性视神经病变是所有成人视神经病变中最常见的，为研究神经保护提供了理想的灵长类和低等哺乳动物动物模型。最近的发现：这一点尤其引人注目，因为虽然最近对青光眼的研究表明降低眼压 (IOP) 是治疗青光眼性视神经病变的有效方式，但并非所有患者都能有效降低眼压或实现有意义的眼压降低。因此，现在很多注意力都集中在神经保护作为青光眼性视神经病治疗策略上，作为保护视网膜神经节细胞及其轴突投射的一种手段。 摘要：这篇综述讨论了青光眼性视神经病治疗中各种神经保护机制的最新研究。
PURPOSE OF REVIEW: Efforts to discover modalities and pathophysiologies that might afford successful neurorescue, neurorestoration, and neuroprotection of cells of the central nervous system have focused on processes that affect the central nervous system proper, that is, the brain. Often overlooked in the search for neural protection is the fact that the mammalian optic nerve behaves in many ways as an integral part of the central nervous system. As such, the eye--the optic nerve and retina--affords an ideal clinical model for neuroprotection and neuroprotective agents. Glaucomatous optic neuropathy is the most prevalent of all adult optic neuropathies, and offers an ideal primate and lower mammalian animal model for investigations of neuroprotection.RECENT FINDINGS: This is especially compelling because while recent studies in glaucoma have shown reduction of intraocular pressure (IOP) to be an effective modality in the treatment of glaucomatous optic neuropathy, not all patients respond to or can achieve meaningful IOP reductions. Therefore much attention has now been focused on neuroprotection as a strategy in therapies for glaucomatous optic neuropathy as a means of preserving retinal ganglion cells and their axonal projections.SUMMARY: This review discusses the latest studies on various mechanisms of neuroprotection in the treatment of glaucomatous optic neuropathy.