Energy Metabolism in Mouse Pancreas in Response to Different Dosages of a CCK Analogue
Energy Metabolism in Mouse Pancreas in Response to Different Dosages of a CCK Analogue
复制标题
小鼠胰腺能量代谢对不同剂量 CCK 类似物的反应
作者：
R. Lüthen;Claw Niederau;L. Ferrell;J. Grendell
用胆囊收缩素类似物刺激胰腺外分泌导致各种腺泡内过程，许多过程与能量消耗相关。据推测，广泛的ATP耗竭可能在急性胰腺炎的病理生理学中发挥作用，特别是在过度刺激（雨蛙素）模型中。小鼠每隔一小时接受七次蛙皮素腹膜内注射，剂量范围从生理学（0.1 μg/kg）到药理学（50 μg/kg）。单剂量雨蛙肽诱导ATP降低28-33%，而完整的注射过程导致最低点低至对照值的45%。观察到的时间过程中ATP组织含量的总体模式在所有四个组中惊人地相似，并且在任何时间点都没有统计学差异。直至12 h，各组的ATP水平均低于对照值。与此相反，血清淀粉酶和光学显微镜反映了胰腺炎的程度在一个密切的剂量反应模式，以管理雨蛙肽剂量。这些结果表明，ATP耗竭，虽然可能促进腺泡损伤，似乎并没有发挥因果关系或主要作用，在急性胰腺炎的病理生理。
Stimulation of the exocrine pancreas with cholecystokinin analogues leads to a variety of intraacinar processes, many coupled to energy consumption. It was hypothesized that extensive ATP depletion could play a role in the pathophysiology of acute pancreatitis, especially in the hyperstimulation (cerulein) model. Mice received seven intraperitoneal injections of cerulein at hourly intervals, at doses ranging from physiological (0.1 μg/kg) to pharmacological (50 μg/kg). A single dose of cerulein induced a 28–33% decrease in ATP, whereas a complete course of injections led to a nadir as low as 45% of the control value. The overall pattern of ATP tissue content during the observed time course was surprisingly similar in all four groups and statistically not different at any time point. Until 12 h, ATP levels in all groups remained below the control value. In contrast, serum amylase and light microscopy reflected a degree of pancreatitis in a close dose-response pattern to the administered cerulein dose. These findings suggest that ATP depletion—although probably facilitating acinar damage—does not seem to play a causal or primary role in the pathophysiology of acute pancreatitis.
胰腺腺泡细胞的钙转运途径。
影响因子：
18.2
作者：
Muallem,S
通讯作者：
Muallem,S
影响因子：
5.5
作者：
Wang, Meng;You, Qiang;Ju, Cynthia
通讯作者：
Ju, Cynthia