Validity and reliability of the CERAD-Col neuropsychological battery
Validity and reliability of the CERAD-Col neuropsychological battery
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DOI：
10.33588/rn.4511.2007086
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发表时间：
2007-12-01
影响因子：
1.2
通讯作者：
Lopera, F.
中科院分区：
文献类型：
--
作者：
Aguirre-Acevedo, D. C.;Gomez, R. D.;Lopera, F.
导论.阿尔茨海默病（AD）因其致残性以及高昂的个人、家庭和社会成本而成为一个重要的公共卫生问题。CERAD神经心理成套测验已被广泛用于评估和诊断与AD相关的认知缺陷。该仪器已适应哥伦比亚文化（CERAD-Col），为神经科学集团。主题和方法。进行了一项研究，以建立CERAD-Col的有效性和可靠性在哥伦比亚，西班牙语的个人年龄在50岁或以上。其中包括151名对照和151名AD患者。对照组是从848名50岁或以上成年人的便利样本中选出的。结构效度的测定方法有三种：1）因子分析; 2）与功能量表FAST和GDS的相关性（收敛型效度）; 3）两组之间的比较。内部一致性通过Cronbach’s α系数确定。结果三个因素-记忆，语言和实践-解释了总方差的88%。神经心理学测试和功能量表之间存在中度但具有统计学意义的相关性。内部一致性和重测重现性高。AD组各项评分均显著低于对照组（p < 0.05）。结论CERAD-Col对于50岁或以上的哥伦比亚西班牙语人群的AD诊断是有效和可靠的。
Introduction. Alzheimer's disease (AD) is an iniportant public health problem due to its disabling character and high individual, familial and social costs. The CERAD neuropsychological battery has been widely used for evaluation and diagnosis of the cognitive deficit associated with AD. This instrument has been adapted to the Colombian culture (CERAD-Col),for the Neurosciences Group. Subjects and methods. A study was carried out to establish the validity and reliability of the CERAD-Col in Colombian, Span ish-speaking individuals aged 50 years or more. It included 151 controls and 151 AD patients. Controls were selected from a convenience sample of 848 adults aged 50 years or more. The construct validity was determined in three ways:1) factorial analysis; 2) correlation with the functional scales FAST and GDS (convergent-type validity) and, 3) comparison between the two groups. Internal consistency was determined by means of Cronbach's alpha coefficient. Results. Three factors -memory, language and praxis- explained 88% of the total variance. Moderate but statistically significant correlations were found between neuropsychological tests and functional scales. Internal consistency and test-retest reproducibility were high. The AD group exhibited significantly lower scores (p < 0.05) than the control one. Conclusion. CERAD-Col is valid and reliable for the diagnosis of AD in Colombian Spanish-speaking population aged 50 years or more.