Cyclic heptapeptides from the Jamaican sponge Stylissa caribica
Cyclic heptapeptides from the Jamaican sponge Stylissa caribica
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DOI：
10.1021/np060006n
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发表时间：
2006-12-01
影响因子：
5.1
通讯作者：
Hamann, Mark. T.
中科院分区：
文献类型：
--
作者：
Mohammed, Rabab;Peng, Jiangnan;Hamann, Mark. T.
除环状七肽phakellistatin 13(3)和已知溴吡啶生物碱sceptrin(4)、stevensine(5)和oroidin(6)外，还从牙买加海绵Stylissa caribica中分离出两个新的环状七肽，stylisin1(1)和stylisin2(2)。新的结构是根据一维和二维核磁共振波谱数据以及化学方法对氨基酸的绝对构型进行确定的。这些肽和生物碱的抗菌、抗疟疾、抗癌、抗hiv -1、抗结核和抗炎活性已被评估。
Two new cyclic heptapeptides, stylisin 1( 1) and stylisin 2 ( 2), were isolated and characterized from the Jamaican sponge Stylissa caribica, in addition to the cyclic heptapeptide phakellistatin 13 ( 3) and the known bromopyrrole alkaloids sceptrin (4), stevensine (5), and oroidin (6). The new structures were assigned on the basis of 1D and 2D NMR spectroscopic data, as well as chemical methods for the elucidation of the absolute configuration of amino acids. The peptides and alkaloids have been evaluated for their antimicrobial, antimalarial, anticancer, anti-HIV-1, anti-Mtb, and antiinflammatory activities.