Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis
Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis
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DOI：
10.1159/000080061
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发表时间：
2004-01-01
期刊：
影响因子：
5
通讯作者：
Suzuki, T
中科院分区：
文献类型：
--
作者：
Hashimoto, T;Kusakabe, T;Suzuki, T
目的：脂肪酸结合蛋白（FABP）通过长链脂肪酸的细胞内转运参与脂质代谢。据报道，心型(H-)FABP可抑制细胞生长并诱导细胞分化，但据我们所知，H-FABP在人胃癌中表达的意义尚未阐明。本研究的目的是检查 H-FABP 的表达及其与胃癌临床病理参数和脂肪酸合酶 (FAS) 状态的关系，因为胃癌显示 FAS 表达增加。方法：用抗 H-FABP 抗体对 669 例胃癌和 60 例胃管状腺瘤进行免疫组织化学分析。分析 H-FABP 阳性和 H-FABP 阴性癌的临床病理特征和 FAS 状态。结果：没有一个腺瘤表达 H-FABP，而 669 例癌中有 127 例 (19.0%) 该蛋白呈阳性。 H-FABP 阳性与浸润深度 (p < 0.0001)、血管浸润 (p < 0.0001)、淋巴结转移 (p < 0.0001) 相关。
Objective: Fatty acid-binding proteins (FABPs) are involved in lipid metabolism by intracellular transport of long-chain fatty acids. Heart-type (H-)FABP has been reported to inhibit cell growth and induce cell differentiation, but to our knowledge the significance of H- FABP expression in human gastric carcinoma has not been elucidated. The aim of the current study was to examine the expression of H- FABP and its relation to clinicopathologic parameters and fatty acid synthase (FAS) status of gastric carcinoma, since gastric cancer shows increased expression of FAS. Methods: Immunohistochemistry with anti-H-FABP antibody was performed in 669 gastric carcinomas and 60 tubular adenomas of the stomach. H-FABP-positive and H-FABP-negative carcinomas were analyzed for their clinicopathologic characteristics and FAS status. Results: None of the adenomas expressed H-FABP, whereas 127 of 669 carcinomas (19.0%) were positive for the protein. H-FABP positivity was associated with the depth of invasion (p < 0.0001), vascular invasion (p < 0.0001), lymph node metastasis (p