V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze
V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze
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DOI：
10.1016/j.neulet.2003.11.050
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发表时间：
2004-02-19
影响因子：
2.5
通讯作者：
Fujiwara, M
中科院分区：
文献类型：
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作者：
Egashira, N;Tanoue, A;Fujiwara, M
在这项研究中，我们在八安径向迷宫中检查了加压素 V1a 受体 (V1aR) 和加压素 V1b 受体 (V1bR) 敲除 (KO) 小鼠与野生型 (WT) 小鼠的表现。与 WT 小鼠相比，V1aR KO 小鼠表现出空间记忆受损。相比之下，我们在八臂径向迷宫中没有观察到 V1bR KO 小鼠和 WT 小鼠之间有任何显着差异。此外，选择性 V1aR 拮抗剂 OPC-21268 会损害 WT 小鼠八安径向迷宫的空间记忆，其特征是错误数量增加。这些结果表明 V1aR 控制小鼠的空间记忆。 (C) 2003 Elsevier Ireland Ltd. 保留所有权利。
in this study, we examined the performance of vasopressin V1a receptor (V1aR) and vasopressin V1b receptor (V1bR) knockout (KO) mice compared to wild-type (WT) mice in an eight-ann radial maze. V1aR KO mice exhibited an impairment of spatial memory in comparison to WT mice. By contrast, we did not observe any significant differences between the V1bR KO mice and the WT mice in the eight-arm radial maze. Moreover, OPC-21268, a selective V1aR antagonist, impaired spatial memory in the eight-ann radial maze in WT mice characterized by an increased number of errors. These results suggest that the V1aR controls spatial memory in mice. (C) 2003 Elsevier Ireland Ltd. All rights reserved.