IMMUNE-REACTIONS IN EPIDERMODYSPLASIA VERRUCIFORMIS
IMMUNE-REACTIONS IN EPIDERMODYSPLASIA VERRUCIFORMIS
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DOI：
10.1111/j.1365-2133.1980.tb08136.x
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发表时间：
1980-01-01
影响因子：
10.3
通讯作者：
KUISMANEN, E
中科院分区：
文献类型：
--
作者：
PYRHONEN, S;JABLONSKA, S;KUISMANEN, E
采用免疫扩散法和酶联免疫吸附法检测了12例疣状表皮发育不良（EV）患者血清中人乳头瘤病毒（HPV）抗体。将结果与66名患有其他类型人乳头状瘤病毒疾病的患者的结果进行比较。EV患者的抗体阳性率略低于对照组。更值得注意的是EV患者和对照组之间的非特异性细胞介导的免疫试验的差异，这是显着的抑郁症在大多数EV患者，但保留在普通疣患者。没有特定的免疫学参数与EV病变的恶性转化相关，但恶性程度与诱导病毒的性质有关，特别是与HPV 5型有关。
Serum antibodies against human papilloma virus [HPV] were measured using immunodiffusion and enzyme-linked immunosorbent assay in 12 patients with epidermodysplasia verruciformis (EV). The results were compared with those from 66 patients with other types of human papilloma virus diseases. Antibody prevalences were slightly lower in patients with EV than in the control patients. More remarkable was the difference between EV patients and control subjects in tests of non-specific cell-mediated immunity, which was markedly depressed in the majority of patients with EV, but preserved in patients with common warts. No specific immunological parameter was associated with malignant conversion of EV lesions, but malignancy was linked to the character of the inducing virus, and particularly to HPV type 5.