PET study of carbon-11-PK 11195 binding to peripheral type benzodiazepine sites in glioblastoma: a case report.
PET study of carbon-11-PK 11195 binding to peripheral type benzodiazepine sites in glioblastoma: a case report.
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胶质母细胞瘤中碳-11-PK 11195 与外周型苯二氮卓位点结合的 PET 研究：病例报告。
DOI：
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发表时间：
1991
影响因子：
9.3
通讯作者：
André Syrota
中科院分区：
文献类型：
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作者：
Sabina Pappatà;Philippe Cornu;Yves Samson;C. Prenant;J. Benavides;B. Scatton;Christian Crouzel;J. Hauw;André Syrota
外周型苯二氮卓类药物位点配体11C-PK 11195的应用，与正电子发射断层成像一起用于人类胶质瘤成像，依赖于示踪剂对肿瘤外周型苯二氮卓类药物位点的高特异性结合。在一名胶质母细胞瘤患者中，我们发现11C-PK 11195在肿瘤中的结合是正常灰质的两倍，并且30%的肿瘤结合可能被大量过量的未标记药物所取代。这些发现表明，配体在肿瘤中的保留部分是由于特异性结合。
The utility of the peripheral type benzodiazepine site ligand 11C-PK 11195, for imaging human glioma in conjunction with Positron Emission Tomography, relies on a high specific binding of the tracer to tumoral peripheral type benzodiazepines sites. In a patient with glioblastoma, we found that 11C-PK 11195 binding was two-fold higher in the tumor than in normal gray matter and that 30% of tumoral binding could be displaced by a large excess of unlabeled drug. These findings suggest that tumoral retention of the ligand is due, in part, to specific binding.
异喹啉和外周型苯二氮卓类药物在神经胶质瘤中的结合：对诊断成像的影响。
影响因子：
11.2
作者：
Olson,JM;Junck,L;Young,AB;Penney,JB;Mancini,WR
通讯作者：
Mancini,WR