Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets.
Molecular pathogenesis of Ewing sarcoma: new therapeutic and transcriptional targets.
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DOI：
10.1146/annurev-pathol-011110-130237
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Ladanyi M
中科院分区：
文献类型：
--
作者：
Lessnick SL;Ladanyi M
Approximately one-third of sarcomas contain specific translocations. Ewing sarcoma is the prototypical member of this group of sarcomas; it was the first to be recognized pathologically as a singular entity and to have its signature translocation defined cytogenetically, which led to the identification of its key driver alteration, the EWS-FLI1 gene fusion that encodes this aberrant, chimeric transcription factor. Here, we review recent progress in selected areas of Ewing sarcoma research, including the application of genome-wide chromatin immunoprecipitation analyses, to provide a comprehensive view of the EWS-FLI1 target gene repertoire, the identification of EWS-FLI1 target genes that may also point to therapeutically targetable pathways, and data from model systems as they relate to the elusive cell of origin of Ewing sarcoma and its possible similarities to mesenchymal stem cells.
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DOI：
10.1073/pnas.0801073105
发表时间：
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通讯作者：
Lessnick, Stephen L.