Dynamics of repeat polymorphisms under a forward-backward mutation model: within- and between-population variability at microsatellite loci.
Dynamics of repeat polymorphisms under a forward-backward mutation model: within- and between-population variability at microsatellite loci.
复制标题
前向-后向突变模型下重复多态性的动态：微卫星位点的群体内和群体间变异性。
DOI：
10.1093/genetics/143.1.549
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发表时间：
1996
期刊：
影响因子：
3.3
通讯作者：
Deka,R
中科院分区：
文献类型：
--
作者：
Kimmel,M;Chakraborty,R;Stivers,DN;Deka,R
新的简单序列串联重复序列的产生的分子机制表明，微卫星位点通过某种形式的向前-向后突变进化。我们提供了一个数学基础，提出了一个衡量群体之间的遗传距离的基础上微卫星变异。我们的研究结果表明，这样的遗传距离的措施，可以保持成比例的群体的分歧时间，即使当正向-反向突变产生变量和/或定向偏置的等位基因大小的变化。如果群体大小和突变率保持不变，则该度量将与群体的分歧时间成比例。该遗传距离以等位基因大小的方差分量的比率表示，基于为研究数量性状的群体动态而开发的表达式。应用这一措施的18个微卫星位点在9个人类种群的数据导致进化树与已知的人种史的人口。
Suggested molecular mechanisms for the generation of new tandem repeats of simple sequences indicate that the microsatellite loci evolve via some form of forward-backward mutation. We provide a mathematical basis for suggesting a measure of genetic distance between populations based on microsatellite variation. Our results indicate that such a genetic distance measure can remain proportional to the divergence time of populations even when the forward-backward mutations produce variable and/or directionally biased alleles size changes. If the population size and the rate of mutation remain constant, then the measure will be proportional to the time of divergence of populations. This genetic distance is expressed in terms of a ratio of components of variance of allele sizes, based on expressions developed for studying population dynamics of quantitative traits. Application of this measure to data on 18 microsatellite loci in nine human populations leads to evolutionary trees consistent with the known ethnohistory of the populations.