Gold nanocages with built-in artificial antibodies for label-free plasmonic biosensing
Gold nanocages with built-in artificial antibodies for label-free plasmonic biosensing
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DOI：
10.1039/c3tb21551b
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发表时间：
2014-01-01
影响因子：
7
通讯作者：
Singamaneni, Srikanth
中科院分区：
文献类型：
--
作者：
Tian, Limei;Liu, Keng-Ku;Singamaneni, Srikanth
我们证明，内置人工抗体的金纳米笼（aunc）能够检测合成尿液中的肾损伤生物标志物，浓度低至25 ng ml（-1）。分子印迹aunc对许多干扰性尿蛋白具有优异的选择性，并且在很宽的pH和比重范围内具有显著的稳定性。
We demonstrate that gold nanocages (AuNCs) with built-in artificial antibodies enable the detection of kidney injury biomarker from synthetic urine down to a concentration of 25 ng ml(-1). Molecularly imprinted AuNCs exhibit excellent selectivity against numerous interfering urinary proteins and remarkable stability over a wide range of pH and specific gravity.