The impact of blunt use on smoking abstinence among Black adults: Secondary analysis from randomized controlled smoking cessation clinical trial.
The impact of blunt use on smoking abstinence among Black adults: Secondary analysis from randomized controlled smoking cessation clinical trial.
复制标题
直接使用对黑人成年人戒烟的影响：随机对照戒烟临床试验的二次分析。
DOI：
10.1016/j.addbeh.2023.107877
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发表时间：
2024
影响因子：
4.4
通讯作者：
SandersonCox,Lisa
中科院分区：
文献类型：
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作者：
Lambart,Leah;Nollen,NicoleL;Mayo,MatthewS;Funk,Olivia;Leavens,Eleanor;Cruvinel,Erica;Brown,Alexandra;Ahluwalia,JasjitS;SandersonCox,Lisa
吸烟的人比不吸烟的人更有可能使用大麻，包括blunts，一种含有尼古丁和大麻的烟草产品。钝性代表了戒烟试验的一个挑战，因为尼古丁可能会使戒烟更加困难。很少有研究探讨了个人积极参与戒烟attempt.MethodsBlunt使用的影响进行了评估，在基线，第4，8，12，16，和26周之间的黑人成年人谁吸烟登记在一个双盲，安慰剂对照，随机试验伐尼克兰（VAR，n = 300）与安慰剂（PBO，n = 200）戒烟。将参与者分类为曾经钝性（在任何时间点报告钝性使用）与非钝性（未报告钝性使用）。主要结局是第12周和第26周时唾液可替宁验证的7天时点戒烟率。结果75例患者（平均年龄45. 6岁（SD = 12. 5，范围：22，80）; 32例（42%）女性）报告使用钝器。逻辑回归分析显示，在第12周或第26周，钝性使用相互作用或钝性使用对戒烟的显著主效应均未导致治疗（p > 0.05）。在调整治疗后，使用钝头器的患者在第12周戒烟的几率在统计学上相似（OR：0.68，95% CI：0.31，1.5）和第26周（OR：0.84，95% CI：0.38,（1.87）在戒烟的参与者中，使用钝性香烟对戒烟没有统计学上的显著影响。临床试验需要在今后的试验中，停止使用的目标是所有可燃产品。
IntroductionPeople who smoke cigarettes are more likely than people who do not to use cannabis, including blunts, a tobacco product containing nicotine and marijuana. Blunts represent a challenge for cessation trials because nicotine could make stopping cigarettes more difficult. Few studies have examined the impact of blunt use on individuals actively engaged in a cigarette quit attempt.MethodsBlunt use was assessed at baseline, Weeks 4, 8, 12, 16, and 26 among Black adult people who smoke enrolled in a double-blind, placebo-controlled, randomized trial of varenicline (VAR, n = 300) versus placebo (PBO, n = 200) for smoking cessation. Participants were categorized as ever blunt (blunt use reported at any timepoint) versus non-blunt (no blunt use reported). The primary outcome was salivary cotinine-verified 7-day point prevalence smoking abstinence at Weeks 12 and 26. Logistic regression examined the effects of treatment and blunt use on abstinence.Results75 participants (mean age 45.6 years (SD = 12.5, range: 22,80); 32 (42%) female) reported blunt use. Logistic regression analyses showed no treatment by blunt use interaction or significant main effect of blunt use on smoking abstinence at Weeks 12 or 26 (p > 0.05). After adjusting for treatment, those who used blunts had statistically similar odds of quitting at Week 12 (OR: 0.68, 95% CI: 0.31, 1.5) and Week 26 (OR: 0.84, 95% CI: 0.38, 1.87) as those who never used blunts during the study.DiscussionBlunt use had no statistically significant impact on cessation among participants in a smoking cessation clinical trial. Future trials are needed in which the target of cessation is all combustible products.