The Multiple Risk Factor Intervention Trial
The Multiple Risk Factor Intervention Trial
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DOI：
10.1007/978-3-642-70296-9_2
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
J. Stamler
中科院分区：
文献类型：
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作者：
J. Stamler
多危险因素干预试验（MRFIT）的科学背景是来自医学研究所有分支（临床和病理调查、流行病学、动物实验）的广泛数据集，这些数据表明生活方式（特别是饮食和吸烟习惯）、与生活方式相关的危险因素与西方工业化国家流行性早发冠心病（CHD）的发生之间存在关系。正如反复指出的那样，这些数据表明，通过改善生活方式和控制既定的主要危险因素，可以预防冠心病。表1给出了三个主要危险因素（血清胆固醇、血压和吸烟）对冠心病首次重大事件发生风险影响的代表性流行病学数据。
The scientific background of the Multiple Risk Factor Intervention Trial (MRFIT) was the extensive set of data from all branches of medical research (clinical and pathologic investigation, epidemiology, animal experimentation) demonstrating a relationship between life-styles (particularly eating and smoking habits), life-style-related risk factors, and the occurrence of epidemic premature coronary heart disease (CHD) in Western industrialized countries. As repeatedly noted, these data indicate the possibility of CHD prevention by improving life-styles and controlling established major risk factors. Table 1 presents representative epidemiologic data on the impact on risk of first major events of coronary heart disease of the three major established risk factors, serum cholesterol, blood pressure, and cigarette use [1].