Colorectal Cancer Stem Cells: Biology and Therapeutic Implications.
Colorectal Cancer Stem Cells: Biology and Therapeutic Implications.
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DOI：
10.1007/s11888-011-0093-2
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发表时间：
2011-06
影响因子：
--
通讯作者：
Frank, Natasha Y
中科院分区：
文献类型：
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作者：
Wilson, Brian J;Schatton, Tobias;Frank, Markus H;Frank, Natasha Y
癌症是由肿瘤起始细胞或癌症干细胞（CSC）亚群驱动的假设，由其广泛自我更新的选择能力和通过分化产生非致瘤性癌细胞后代的能力定义，已在多种人类恶性肿瘤中得到实验验证。CSC假设的翻译相关性通过新兴的新策略来强调，这些新策略旨在靶向给定肿瘤内的所有亚群，以实现癌症根除并改善患者结局。结直肠癌干细胞（CRSC）已被确定和成功分离的几个研究小组基于不同的细胞表面标记特征。CRSC群体的鉴定导致了一系列发现，描述了结直肠癌中代表新的未来治疗靶点的新的自我更新和耐药机制。在这篇综述中，我们将讨论新出现的CRSC特异性通路和靶向结直肠癌患者中这一癌症人群的治疗前景。
The hypothesis that cancer is driven by a subpopulation of tumor-initiating or cancer stem cells (CSC), defined by their selective ability for extensive self-renewal and capacity to give rise to nontumorigenic cancer cell progeny through differentiation, has been validated experimentally in diverse human malignancies. Translational relevance of the CSC hypothesis is underlined by emerging novel strategies designed to target all subpopulations within a given tumor in order to effect cancer eradication and improve patient outcomes. Colorectal cancer stem cells (CRSCs) have been identified and successfully isolated by several research groups based on distinct cell-surface marker characteristics. Identification of CRSC populations has led to a wave of discoveries describing novel self-renewal and drug resistance mechanisms in colorectal cancer that represent novel future therapeutic targets. In this review, we will discuss emerging CRSC-specific pathways and the therapeutic promise of targeting this cancer population in colorectal cancer patients.