Functional coherence of insula networks is associated with externalizing behavior.
Functional coherence of insula networks is associated with externalizing behavior.
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DOI：
10.1037/abn0000078
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发表时间：
2015-11
影响因子：
4.6
通讯作者：
DeYoung CG
中科院分区：
文献类型：
--
作者：
Abram SV;Wisner KM;Grazioplene RG;Krueger RF;MacDonald AW;DeYoung CG
外化谱包括一系列适应不良行为，包括物质使用问题、冲动和攻击性。虽然之前的文献将外化行为与前额叶和杏仁核异常联系起来，但最近的研究表明岛叶功能也与此有关。本研究调查了大型社区样本（N = 244）中岛叶功能一致性和外化之间的关系。参与者接受了静息功能磁共振成像扫描。完成独立成分分析后，确定了三个主要涉及岛叶的非人工内在连接网络（ICN）。三个外化领域——一般去抑制、药物滥用和冷酷的攻击——通过外化频谱清单进行测量。回归模型测试了三个岛叶 ICN 的网络内一致性是否与每个外部化域相关。后岛叶一致性与一般去抑制和药物滥用呈正相关。前岛叶/腹侧纹状体/前扣带回网络一致性与一般去抑制呈负相关。岛叶一致性与冷酷的攻击域无关。后续分析表明，与其他额叶和边缘 ICN 相比，岛叶 ICN 在与一般去抑制和药物滥用的关系方面具有特异性。这项研究发现岛叶网络一致性与社区参与者的外化行为显着相关。包含较少岛叶皮质的额叶和边缘 ICN 与外化无关。因此，岛叶网络的神经同步性可能是理解外化精神病理学的核心。
The externalizing spectrum encompasses a range of maladaptive behaviors, including substance use problems, impulsivity, and aggression. While previous literature has linked externalizing behaviors with prefrontal and amygdala abnormalities, recent studies suggest insula functionality is implicated. The present study investigated the relation between insula functional coherence and externalizing in a large community sample (N=244). Participants underwent a resting functional magnetic resonance imaging scan. Three non-artifactual intrinsic connectivity networks (ICNs) substantially involving the insula were identified after completing independent components analysis. Three externalizing domains—general disinhibition, substance abuse, and callous aggression—were measured with the Externalizing Spectrum Inventory. Regression models tested whether within-network coherence for the three insula ICNs was related to each externalizing domain. Posterior insula coherence was positively associated with general disinhibition and substance abuse. Anterior insula/ventral striatum/anterior cingulate network coherence was negatively associated with general disinhibition. Insula coherence did not relate to the callous aggression domain. Follow-up analyses indicated specificity for insula ICNs in their relation to general disinhibition and substance abuse as compared to other frontal and limbic ICNs. This study found insula network coherence was significantly associated with externalizing behaviors in community participants. Frontal and limbic ICNs containing less insular cortex were not related to externalizing. Thus, the neural synchrony of insula networks may be central for understanding externalizing psychopathology.