Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens
Suadimins A-C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from Melodinus suaveolens
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Suadimins A-C，来自 Melodinus suaveolens 的前所未有的具有抗分枝杆菌活性的二聚喹啉生物碱
DOI：
10.1021/acs.orglett.9b02630
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发表时间：
2019-09-06
期刊：
影响因子：
5.2
通讯作者：
Yue, Jian-Min
中科院分区：
文献类型：
--
作者：
Gao, Xin-Hua;Fan, Yao-Yue;Yue, Jian-Min
The suadimins A-C (1-3) from Melodinus suaveolens are the first example of monoterpenoid quinoline alkaloid dimers featuring an unprecedented carbon skeleton. Their structures and absolute configurations were established on the basis of extensive spectroscopic analyses, electric circular dichroism (ECD), and X-ray crystallography. Suadimin A showed significant antimycobacterial activity in vitro with an MIC90 of 6.76 mu M against the H(37)Rv strain of M. tuberculosis.
