Modulating T Cell Phenotype and Function to Treat Hypertension.
Modulating T Cell Phenotype and Function to Treat Hypertension.
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DOI：
10.34067/kid.0000000000000090
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发表时间：
2023-04-01
期刊：
影响因子：
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通讯作者：
Madhur MS
中科院分区：
文献类型：
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作者：
Fehrenbach DJ;Nguyen B;Alexander MR;Madhur MS
高血压是世界范围内发病率和死亡率的主要可改变危险因素，因为它对心血管和肾终末器官的损害有影响。不幸的是，血压控制并不足以完全降低高血压的风险，因此需要新的治疗方法来解决高血压终末器官损伤。在过去的几十年里，免疫激活和高血压之间的联系已经得到了很好的确立，但仍然没有专门针对免疫系统的高血压治疗方法。在这篇综述中，我们描述了T细胞在高血压和高血压终末器官损伤中的关键作用，并概述了在不引起全局免疫抑制的情况下调节高血压中T细胞表型和功能的潜在治疗靶点。
Hypertension is the leading modifiable risk factor of worldwide morbidity and mortality because of its effects on cardiovascular and renal end-organ damage. Unfortunately, BP control is not sufficient to fully reduce the risks of hypertension, underscoring the need for novel therapies that address end-organ damage in hypertension. Over the past several decades, the link between immune activation and hypertension has been well established, but there are still no therapies for hypertension that specifically target the immune system. In this review, we describe the critical role played by T cells in hypertension and hypertensive end-organ damage and outline potential therapeutic targets to modulate T-cell phenotype and function in hypertension without causing global immunosuppression.