Schistosoma haematobium and Schistosomiasis mansoni: Production of an estradiol-related compound detected by elisa
Schistosoma haematobium and Schistosomiasis mansoni: Production of an estradiol-related compound detected by elisa
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DOI：
10.1016/j.exppara.2009.04.001
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发表时间：
2009-07-01
影响因子：
2.1
通讯作者：
Correia da Costa, J. M.
中科院分区：
文献类型：
--
作者：
Botelho, M. C.;Crespo, M.;Correia da Costa, J. M.
雌二醇是一种类固醇激素，主要由脊椎动物的卵泡分泌。我们已经在吸虫、血吸虫、血吸虫和曼氏血吸虫中发现了雌激素相关分子的产生。我们在这项工作中表明，这种与雌二醇相关的分子存在于血吸虫虫体提取物中。通过对雌二醇的检测，发现雌二醇相关分子在血吸虫虫体提取物中有表达，而在肝片吸虫虫体提取物中不表达。我们的结果首次证明了血吸虫属的人类寄生虫产生了一种与雌二醇相关的化合物。(C)2009 Elsevier Inc.保留所有权利。
Estradiol is a steroid hormone secreted principally by the ovarian follicles in vertebrate animals. We have identified the production of an estradiol-related molecule in the trematodes Schistosoma haematobium and Schistosomiasis mansoni. We show in this work that this molecule related to estradiol is present in schistosome worm extracts. The detection method ELISA specific for estradiol, revealed the expression of this estradiol-related molecule in schistosome worm extracts, but not in Fasciola hepatica worm extracts. Our results demonstrate for the first time the production of an estradiol-related compound by a human parasite of the genus Schistosoma. (C) 2009 Elsevier Inc. All rights reserved.