A monoclonal antibody useful for the differential diagnosis between malignant lymphoma and nonhematopoietic neoplasms.
A monoclonal antibody useful for the differential diagnosis between malignant lymphoma and nonhematopoietic neoplasms.
复制标题
一种单克隆抗体，可用于恶性淋巴瘤和非造血肿瘤的鉴别诊断。
DOI：
10.1002/1097-0142(19830301)51:5
复制
发表时间：
1983
期刊：
影响因子：
6.2
通讯作者：
Trowbridge,IS
中科院分区：
文献类型：
--
作者：
Battifora,H;Trowbridge,IS
命名为T29/33的单克隆抗体，其识别造血细胞的主要细胞表面糖蛋白，作为一种可能的工具进行了测试，以区分淋巴瘤与非造血肿瘤具有相似的形态学外观，通过光学显微镜。每40个淋巴瘤研究的免疫荧光和/或免疫过氧化物酶的冷冻切片显示存在相应的抗原，而110个控制肿瘤的各种非造血来源是阴性的。结论是，T29/33抗体可能有助于解决鉴别诊断为非霍奇金淋巴瘤和非淋巴瘤的肿瘤的诊断问题。
A monoclonal antibody designated as T29/33, which recognizes a major cell surface glycoprotein of hematopoietic cells, was tested as a possible tool to distinguish lymphoma from nonhematopoietic tumors having a similar morphologic appearance by light microscopy. Each of the 40 lymphomas studied by immunofluorescence and/or immunoperoxidase on frozen sections revealed the presence of the corresponding antigen, whereas 110 control tumors of various nonhematopoietic origins were negative. It was concluded that the T29/33 antibody may be of value in resolving the diagnostic problems presented by tumors in which the differential diagnosis is between non‐Hodgkin's lymphoma and nonlymphoid tumors.