Tomoelastography Based on Multifrequency MR Elastography for Prostate Cancer Detection: Comparison with Multiparametric MRI
Tomoelastography Based on Multifrequency MR Elastography for Prostate Cancer Detection: Comparison with Multiparametric MRI
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DOI：
10.1148/radiol.2021201852
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发表时间：
2021-05-01
期刊：
影响因子：
19.7
通讯作者：
Li, Wenzheng
中科院分区：
文献类型：
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作者：
Li, Mengsi;Guo, Jing;Li, Wenzheng
背景资料：多参数MRI用于描述前列腺癌（PCa），但没有考虑到前列腺组织的机械改变。目的：研究断层弹性成像（一种多频率MR弹性成像技术）定量的硬度和流动性的诊断性能，与前列腺成像报告和数据系统（PI-RADS）版本2.1的多参数MRI相比，用于描述PCa。材料和方法：疑似PCa和健康对照（HC）的前瞻性参与者在2019年3月至2020年7月期间接受了多参数MRI和断层弹性成像。断层弹性成像图的剪切波速度（c）和损失角（phi）量化硬度和流动性，分别为PCa和良性前列腺疾病和周围和过渡区的HC。采用方差分析或Kruskal-Wallis检验分析实体和地区之间的差异。结果：有73名参与者与PCa（平均年龄，72岁+/- 7 [标准差]），82与良性前列腺疾病（66岁+/- 7），和53 HC（41岁+/- 14）。前列腺癌的c和w的平均值±标准差（分别为3.4 m/sec ± 0.6和1.3弧度± 0.2）高于良性前列腺疾病（分别为2.6 m/sec ± 0.3和1.0弧度± 0.2; P
Background: Multiparametric MRI is used for depiction of prostate cancer (PCa) but without consideration of the mechanical alteration of prostatic tissue by cancer.Purpose: To investigate the diagnostic performance of stiffness and fluidity quantified with tomoelastography, a multifrequency MR elastography technique, for depiction of PCa compared with multiparametric MRI with Prostate Imaging Reporting and Data System (PI-RADS) version 2.1.Materials and Methods: Prospective participants suspected to have PCa and healthy controls (HCs) underwent multiparametric MRIand tomoelastography between March 2019 and July 2020. Tomoelastography maps of shear-wave speed (c) and loss angle (phi) quantified stiffness and fluidity, respectively, for PCa and benign prostatic disease and for the peripheral and transition zones in HCs. Differences between entities and regions were analyzed by using analysis of variance or Kruskal-Wallis test. Diagnostic performance was assessed with area under the receiver operating characteristic curve (AUC) analysis.Results: There were 73 participants with PCa (mean age, 72 years +/- 7 [standard deviation]), 82 with benign prostatic disease (66 years +/- 7), and 53 HCs (41 years +/- 14). Mean +/- standard deviation of c and w were higher in PCa (3.4 m/sec +/- 0.6 and 1.3 radian +/- 0.2, respectively) than in benign prostatic disease (2.6 m/sec +/- 0.3 and 1.0 radian +/- 0.2, respectively; P